node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CF8_1090 | CF8_3881 | CF8_1090 | CF8_3881 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Bifunctional deaminase-reductase-like protein. | 0.608 |
CF8_1090 | gcvP | CF8_1090 | CF8_2030 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.450 |
CF8_1090 | thyA | CF8_1090 | CF8_2437 | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.937 |
CF8_1956 | CF8_3457 | CF8_1956 | CF8_3457 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Riboflavin biosynthesis protein. | 0.626 |
CF8_1956 | CF8_3881 | CF8_1956 | CF8_3881 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Bifunctional deaminase-reductase-like protein. | 0.626 |
CF8_1956 | CF8_3883 | CF8_1956 | CF8_3883 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Short-chain dehydrogenase/reductase SDR. | 0.518 |
CF8_1956 | dapF | CF8_1956 | CF8_3882 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.490 |
CF8_1956 | gcvP | CF8_1956 | CF8_2030 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family. | 0.917 |
CF8_1956 | gcvT | CF8_1956 | CF8_2433 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Glycine cleavage system aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.974 |
CF8_1956 | thyA | CF8_1956 | CF8_2437 | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.662 |
CF8_3457 | CF8_1956 | CF8_3457 | CF8_1956 | Riboflavin biosynthesis protein. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.626 |
CF8_3457 | CF8_3881 | CF8_3457 | CF8_3881 | Riboflavin biosynthesis protein. | Bifunctional deaminase-reductase-like protein. | 0.624 |
CF8_3457 | thyA | CF8_3457 | CF8_2437 | Riboflavin biosynthesis protein. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.639 |
CF8_3880 | CF8_3881 | CF8_3880 | CF8_3881 | Gamma-glutamyltransferase. | Bifunctional deaminase-reductase-like protein. | 0.773 |
CF8_3880 | CF8_3883 | CF8_3880 | CF8_3883 | Gamma-glutamyltransferase. | Short-chain dehydrogenase/reductase SDR. | 0.689 |
CF8_3880 | dapF | CF8_3880 | CF8_3882 | Gamma-glutamyltransferase. | Diaminopimelate epimerase; Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L- lysine and an essential component of the bacterial peptidoglycan. | 0.788 |
CF8_3880 | miaA | CF8_3880 | CF8_3879 | Gamma-glutamyltransferase. | tRNA delta(2)-isopentenylpyrophosphate; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A); Belongs to the IPP transferase family. | 0.744 |
CF8_3881 | CF8_1090 | CF8_3881 | CF8_1090 | Bifunctional deaminase-reductase-like protein. | FolC bifunctional protein; Belongs to the folylpolyglutamate synthase family. | 0.608 |
CF8_3881 | CF8_1956 | CF8_3881 | CF8_1956 | Bifunctional deaminase-reductase-like protein. | B12-dependent methionine synthase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.626 |
CF8_3881 | CF8_3457 | CF8_3881 | CF8_3457 | Bifunctional deaminase-reductase-like protein. | Riboflavin biosynthesis protein. | 0.624 |