STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rskAAnti-sigma K factor; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor SigK. ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut extracytoplasmically (site-1 protease, S1P), then within the membrane itself (site-2 protease, S2P, Rip1), while cytoplasmic proteases finish degrading the regu [...] (232 aa)    
Predicted Functional Partners:
KMV24575.1
RNA polymerase sigma factor SigK; Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; in M. bovis this protein has been shown to be involved in expression of antigenic proteins; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family. ECF subfamily.
 
   
 0.940
KMV24426.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.744
KMV24424.1
Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.705
KMV24425.1
Cyclopropane-fatty-acyl-phospholipid synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.705
KMV24427.1
Amine oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.705
KMV24428.1
Dimethyladenosine transferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.553
KMV14581.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.520
KMV22785.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.504
KMV21898.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.485
KMV21087.1
Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.445
Your Current Organism:
Mycobacterium heckeshornense
NCBI taxonomy Id: 110505
Other names: CCUG 51897, CIP 107347, DSM 44428, JCM 15655, M. heckeshornense, Mycobacterium heckeshornense Roth et al. 2001, strain S369
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.