Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KMV23382.14-carboxymuconolactone decarboxylase; Derived by automated computational analysis using gene prediction method: Protein Homology. (198 aa)    
Predicted Functional Partners:
KMV23381.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.759
KMV21061.1
3-carboxy-cis,cis-muconate cycloisomerase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
  0.755
KMV20854.1
RNA polymerase subunit sigma; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family.
 
    0.638
hrcA
HrcA family transcriptional regulator; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons.
     
 0.550
KMV21062.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
  0.488
KMV22954.1
Pyridoxamine 5'-phosphate oxidase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.442
KMV23820.1
RNA polymerase sigma24 factor; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the sigma-70 factor family.
 
    0.436
dnaJ-2
Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...]
       0.418
KMV23896.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.413
KMV18846.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
  0.409
Your Current Organism:
Mycobacterium heckeshornense
NCBI taxonomy Id: 110505
Other names: CCUG 51897, CIP 107347, DSM 44428, JCM 15655, M. heckeshornense, Mycobacterium heckeshornense Roth et al. 2001, strain S369
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