Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KMV23250.1Ribonucleotide-diphosphate reductase subunit beta; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides; Belongs to the ribonucleoside diphosphate reductase small chain family. (320 aa)    
Predicted Functional Partners:
KMV23206.1
Ribonucleotide-diphosphate reductase subunit alpha; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.
 
 0.999
KMV20933.1
Ribonucleoside-diphosphate reductase; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen.
  
 0.998
nrdI
Ribonucleotide reductase; Probably involved in ribonucleotide reductase function.
 
 
 0.997
gmk
Guanylate kinase; Essential for recycling GMP and indirectly, cGMP.
   
 
 0.987
cmk
Cytidylate kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.978
adk
Adenylate kinase; Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family.
     
 0.962
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.928
KMV23528.1
Ribonucleotide-diphosphate reductase subunit beta; Catalyzes the rate-limiting step in dNTP synthesis; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.923
KMV23252.1
Glutaredoxin; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.914
KMV21881.1
GTP pyrophosphokinase; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
   
 
  0.902
Your Current Organism:
Mycobacterium heckeshornense
NCBI taxonomy Id: 110505
Other names: CCUG 51897, CIP 107347, DSM 44428, JCM 15655, M. heckeshornense, Mycobacterium heckeshornense Roth et al. 2001, strain S369
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