STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KMV22951.1Ring-cleavage extradiol dioxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology. (122 aa)    
Predicted Functional Partners:
KMV21880.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
  0.924
KMV23290.1
Glyoxalase-like protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.903
KMV22819.1
Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.801
KMV22741.1
Monooxygenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.801
trpB
Tryptophan synthase subunit beta; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
     
  0.800
trpA
Tryptophan synthase subunit alpha; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
     
  0.800
ilvA
Threonine dehydratase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA.
     
  0.800
mutA
methylmalonyl-CoA mutase; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.568
KMV21327.1
methylmalonyl-CoA mutase; MDM; functions in conversion of succinate to propionate; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.568
KMV24316.1
Oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.532
Your Current Organism:
Mycobacterium heckeshornense
NCBI taxonomy Id: 110505
Other names: CCUG 51897, CIP 107347, DSM 44428, JCM 15655, M. heckeshornense, Mycobacterium heckeshornense Roth et al. 2001, strain S369
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