Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KMV21694.1ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. (299 aa)    
Predicted Functional Partners:
KMV21695.1
ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.996
KMV21696.1
DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.996
KMV22092.1
DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.979
KMV23864.1
ATP-dependent DNA ligase; Catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA and has been shown to have polymerase activity; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
0.930
ku
DNA repair protein; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.888
ligC
ATP-dependent DNA ligase; Catalyzes the ATP-dependent formation of a phosphodiester at the site of a single-strand break in duplex DNA; in mycobacteria LigC has weak intrinsic nick joining activities and is not essential for growth; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.881
KMV22491.1
ATP-dependent DNA ligase; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.879
KMV21697.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.809
KMV21727.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.689
ligB
ATP-dependent DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
 
   
 0.501
Your Current Organism:
Mycobacterium heckeshornense
NCBI taxonomy Id: 110505
Other names: CCUG 51897, CIP 107347, DSM 44428, JCM 15655, M. heckeshornense, Mycobacterium heckeshornense Roth et al. 2001, strain S369
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