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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KMV21566.1Luciferase; Derived by automated computational analysis using gene prediction method: Protein Homology. (286 aa)    
Predicted Functional Partners:
KMV21565.1
Thioesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.855
glnE
Bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...]
       0.726
KMV21562.1
Hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
  0.704
KMV22754.1
Luciferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.702
KMV21563.1
Glutamine synthetase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the glutamine synthetase family.
       0.687
KMV22893.1
NADP oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.682
KMV23102.1
Luciferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.646
KMV24017.1
Luciferase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.618
KMV23207.1
FMN reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.618
KMV24014.1
FMN reductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.617
Your Current Organism:
Mycobacterium heckeshornense
NCBI taxonomy Id: 110505
Other names: CCUG 51897, CIP 107347, DSM 44428, JCM 15655, M. heckeshornense, Mycobacterium heckeshornense Roth et al. 2001, strain S369
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