Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
KMV18396.1Cysteine hydrolase; Derived by automated computational analysis using gene prediction method: Protein Homology. (213 aa)    
Predicted Functional Partners:
KMV22717.1
Isochorismate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.760
KMV13610.1
Polyketide synthase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.635
KMV22455.1
Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.552
KMV21578.1
Short-chain dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.552
KMV23396.1
Salicylate synthase MbtI; Catalyzes conversion of chorismate to salicylate, in mycobactin siderophore construction; requires Mg(2+) for function; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.502
trpE
Anthranilate synthase component I; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concentr [...]
    
 0.502
nnrD
Membrane protein; Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers [...]
  
    0.501
gcvT
Glycine cleavage system protein T; The glycine cleavage system catalyzes the degradation of glycine.
   
 
 0.482
KMV24241.1
Esterase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  0.480
KMV20829.1
Isochorismatase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.480
Your Current Organism:
Mycobacterium heckeshornense
NCBI taxonomy Id: 110505
Other names: CCUG 51897, CIP 107347, DSM 44428, JCM 15655, M. heckeshornense, Mycobacterium heckeshornense Roth et al. 2001, strain S369
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