MCE_03415 protein (Rickettsia amblyommatis) - STRING interaction network

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Score

MCE_03415

COG0281 Malic enzyme. (767 aa)

Predicted Functional Partners:

MCE_02440

0.999

mdh

0.994

fumC

0.991

pdhA

0.984

gltA

0.979

MCE_04305

0.971

MCE_04950

0.943

MCE_05475

0.934

MCE_07795

0.934

sucC

0.899

Your Current Organism:

Rickettsia amblyommatis

NCBI taxonomy Id: 1105111
Other names: Candidatus Rickettsia amblyommii str. GAT-30V, R. amblyommatis str. GAT-30V, Rickettsia amblyommatis str. GAT-30V

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCE_02440	MCE_03415	MCE_02440	MCE_03415	Pyruvate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	COG0281 Malic enzyme.	0.999
MCE_02440	MCE_04305	MCE_02440	MCE_04305	Pyruvate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Pyruvate phosphate dikinase; COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family.	0.978
MCE_02440	MCE_04950	MCE_02440	MCE_04950	Pyruvate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	COG1250 3-hydroxyacyl-CoA dehydrogenase.	0.962
MCE_02440	MCE_05475	MCE_02440	MCE_05475	Pyruvate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes.	0.999
MCE_02440	MCE_07795	MCE_02440	MCE_07795	Pyruvate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes.	0.999
MCE_02440	fumC	MCE_02440	MCE_06610	Pyruvate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.	0.895
MCE_02440	gltA	MCE_02440	MCE_00120	Pyruvate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	COG0372 Citrate synthase; Belongs to the citrate synthase family.	0.991
MCE_02440	mdh	MCE_02440	MCE_03470	Pyruvate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.	0.956
MCE_02440	pdhA	MCE_02440	MCE_02435	Pyruvate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	Pyruvate dehydrogenase e1 component, alpha subunit precursor; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.999
MCE_02440	sucC	MCE_02440	MCE_03880	Pyruvate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.977
MCE_03415	MCE_02440	MCE_03415	MCE_02440	COG0281 Malic enzyme.	Pyruvate dehydrogenase subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.999
MCE_03415	MCE_04305	MCE_03415	MCE_04305	COG0281 Malic enzyme.	Pyruvate phosphate dikinase; COG0574 Phosphoenolpyruvate synthase/pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family.	0.971
MCE_03415	MCE_04950	MCE_03415	MCE_04950	COG0281 Malic enzyme.	COG1250 3-hydroxyacyl-CoA dehydrogenase.	0.943
MCE_03415	MCE_05475	MCE_03415	MCE_05475	COG0281 Malic enzyme.	COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes.	0.934
MCE_03415	MCE_07795	MCE_03415	MCE_07795	COG0281 Malic enzyme.	COG1249 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes.	0.934
MCE_03415	fumC	MCE_03415	MCE_06610	COG0281 Malic enzyme.	Fumarate hydratase; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.	0.991
MCE_03415	gltA	MCE_03415	MCE_00120	COG0281 Malic enzyme.	COG0372 Citrate synthase; Belongs to the citrate synthase family.	0.979
MCE_03415	mdh	MCE_03415	MCE_03470	COG0281 Malic enzyme.	Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate. Belongs to the LDH/MDH superfamily. MDH type 3 family.	0.994
MCE_03415	pdhA	MCE_03415	MCE_02435	COG0281 Malic enzyme.	Pyruvate dehydrogenase e1 component, alpha subunit precursor; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).	0.984
MCE_03415	sucC	MCE_03415	MCE_03880	COG0281 Malic enzyme.	succinyl-CoA synthetase subunit beta; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.	0.899