| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MCE_00280 | dnaX | MCE_00280 | MCE_00275 | Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. | DNA polymerase III subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.946 |
| MCE_00280 | recR | MCE_00280 | MCE_03955 | Hypothetical protein; Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection. | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.965 |
| MCE_04030 | MCE_04810 | MCE_04030 | MCE_04810 | DNA helicase II; COG0210 Superfamily I DNA and RNA helicases. | COG0350 Methylated DNA-protein cysteine methyltransferase. | 0.647 |
| MCE_04030 | MCE_05155 | MCE_04030 | MCE_05155 | DNA helicase II; COG0210 Superfamily I DNA and RNA helicases. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | 0.804 |
| MCE_04030 | dnaX | MCE_04030 | MCE_00275 | DNA helicase II; COG0210 Superfamily I DNA and RNA helicases. | DNA polymerase III subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.656 |
| MCE_04030 | recF | MCE_04030 | MCE_00760 | DNA helicase II; COG0210 Superfamily I DNA and RNA helicases. | Recombination protein F; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. | 0.550 |
| MCE_04030 | recO | MCE_04030 | MCE_05100 | DNA helicase II; COG0210 Superfamily I DNA and RNA helicases. | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | 0.426 |
| MCE_04030 | recR | MCE_04030 | MCE_03955 | DNA helicase II; COG0210 Superfamily I DNA and RNA helicases. | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.642 |
| MCE_04030 | topA | MCE_04030 | MCE_03065 | DNA helicase II; COG0210 Superfamily I DNA and RNA helicases. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.804 |
| MCE_04030 | uvrC | MCE_04030 | MCE_04850 | DNA helicase II; COG0210 Superfamily I DNA and RNA helicases. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.848 |
| MCE_04810 | MCE_04030 | MCE_04810 | MCE_04030 | COG0350 Methylated DNA-protein cysteine methyltransferase. | DNA helicase II; COG0210 Superfamily I DNA and RNA helicases. | 0.647 |
| MCE_04810 | recF | MCE_04810 | MCE_00760 | COG0350 Methylated DNA-protein cysteine methyltransferase. | Recombination protein F; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. | 0.533 |
| MCE_04810 | recO | MCE_04810 | MCE_05100 | COG0350 Methylated DNA-protein cysteine methyltransferase. | DNA repair protein RecO; Involved in DNA repair and RecF pathway recombination. | 0.577 |
| MCE_04810 | recR | MCE_04810 | MCE_03955 | COG0350 Methylated DNA-protein cysteine methyltransferase. | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.571 |
| MCE_04810 | uvrC | MCE_04810 | MCE_04850 | COG0350 Methylated DNA-protein cysteine methyltransferase. | Excinuclease ABC subunit C; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. | 0.656 |
| MCE_05155 | MCE_04030 | MCE_05155 | MCE_04030 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DNA helicase II; COG0210 Superfamily I DNA and RNA helicases. | 0.804 |
| MCE_05155 | dnaX | MCE_05155 | MCE_00275 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DNA polymerase III subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. | 0.825 |
| MCE_05155 | recF | MCE_05155 | MCE_00760 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | Recombination protein F; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP; Belongs to the RecF family. | 0.467 |
| MCE_05155 | recR | MCE_05155 | MCE_03955 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | Recombination protein RecR; May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. | 0.599 |
| MCE_05155 | topA | MCE_05155 | MCE_03065 | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity and contains distinct active sites for ATP binding, DNA binding, and interaction with DnaC protein, primase, and other prepriming proteins. Belongs to the helicase family. DnaB subfamily. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.613 |