ppnK protein (Rickettsia amblyommatis) - STRING interaction network

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ppnK

Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (255 aa)

Predicted Functional Partners:

MCE_00260

0.917

MCE_00265

0.913

MCE_01350

0.902

MCE_03415

0.702

MCE_05040

0.659

MCE_03975

0.586

MCE_04950

0.485

MCE_01850

0.441

glyA

0.429

coaE

0.422

Your Current Organism:

Rickettsia amblyommatis

NCBI taxonomy Id: 1105111
Other names: Candidatus Rickettsia amblyommii str. GAT-30V, R. amblyommatis str. GAT-30V, Rickettsia amblyommatis str. GAT-30V

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MCE_00260	MCE_00265	MCE_00260	MCE_00265	COG3288 NAD/NADP transhydrogenase alpha subunit.	COG3288 NAD/NADP transhydrogenase alpha subunit.	0.999
MCE_00260	MCE_01350	MCE_00260	MCE_01350	COG3288 NAD/NADP transhydrogenase alpha subunit.	NAD(p) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.	0.999
MCE_00260	MCE_03415	MCE_00260	MCE_03415	COG3288 NAD/NADP transhydrogenase alpha subunit.	COG0281 Malic enzyme.	0.521
MCE_00260	ppnK	MCE_00260	MCE_03970	COG3288 NAD/NADP transhydrogenase alpha subunit.	Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.917
MCE_00265	MCE_00260	MCE_00265	MCE_00260	COG3288 NAD/NADP transhydrogenase alpha subunit.	COG3288 NAD/NADP transhydrogenase alpha subunit.	0.999
MCE_00265	MCE_01350	MCE_00265	MCE_01350	COG3288 NAD/NADP transhydrogenase alpha subunit.	NAD(p) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.	0.999
MCE_00265	MCE_03415	MCE_00265	MCE_03415	COG3288 NAD/NADP transhydrogenase alpha subunit.	COG0281 Malic enzyme.	0.521
MCE_00265	ppnK	MCE_00265	MCE_03970	COG3288 NAD/NADP transhydrogenase alpha subunit.	Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.913
MCE_01350	MCE_00260	MCE_01350	MCE_00260	NAD(p) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.	COG3288 NAD/NADP transhydrogenase alpha subunit.	0.999
MCE_01350	MCE_00265	MCE_01350	MCE_00265	NAD(p) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.	COG3288 NAD/NADP transhydrogenase alpha subunit.	0.999
MCE_01350	ppnK	MCE_01350	MCE_03970	NAD(p) transhydrogenase subunit beta; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.	Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.902
MCE_01850	glyA	MCE_01850	MCE_07325	DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.416
MCE_01850	ppnK	MCE_01850	MCE_03970	DNA repair protein RecN; May be involved in recombinational repair of damaged DNA.	Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.441
MCE_03415	MCE_00260	MCE_03415	MCE_00260	COG0281 Malic enzyme.	COG3288 NAD/NADP transhydrogenase alpha subunit.	0.521
MCE_03415	MCE_00265	MCE_03415	MCE_00265	COG0281 Malic enzyme.	COG3288 NAD/NADP transhydrogenase alpha subunit.	0.521
MCE_03415	MCE_04950	MCE_03415	MCE_04950	COG0281 Malic enzyme.	COG1250 3-hydroxyacyl-CoA dehydrogenase.	0.892
MCE_03415	coaE	MCE_03415	MCE_07150	COG0281 Malic enzyme.	dephospho-CoA kinase; Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; Belongs to the CoaE family.	0.582
MCE_03415	glyA	MCE_03415	MCE_07325	COG0281 Malic enzyme.	Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.	0.722
MCE_03415	ppnK	MCE_03415	MCE_03970	COG0281 Malic enzyme.	Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.702
MCE_03975	ppnK	MCE_03975	MCE_03970	Hypothetical protein; COG0595 Predicted hydrolase of the metallo-beta-lactamase superfamily.	Inorganic polyphosphate/ATP-NAD kinase; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.	0.586

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