STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
CPR21456.1Thioredoxin. (417 aa)    
Predicted Functional Partners:
CPR20876.1
Thioredoxin reductase.
 
 
 0.855
CPR21455.1
TldE protein, part of TldE/TldD proteolytic complex.
       0.777
TldD
TldD protein, part of TldE/TldD proteolytic complex.
       0.741
CPR21458.1
ABC transporter ATP binding component.
       0.730
CPR21460.1
Ferrichrome-iron receptor.
       0.703
fur
Ferric uptake regulation protein FUR; Belongs to the Fur family.
  
 
 0.611
grpE
Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]
 
  
 0.581
hslU
ATP-dependent hsl protease ATP-binding subunit HslU; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.
  
 
 0.580
groEL
Heat shock protein 60 family chaperone GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.
 
 
 0.577
CPR13641.1
Low molecular weight protein-tyrosine-phosphatase Wzb.
  
 
 0.562
Your Current Organism:
Brenneria goodwinii
NCBI taxonomy Id: 1109412
Other names: B. goodwinii, BCC 845, Brenneria goodwinii Denman et al. 2012, Brenneria sp. LMG 26270, Brenneria sp. LMG 26271, Brenneria sp. LMG 26272, Brenneria sp. R-43476, Brenneria sp. R-43477, Brenneria sp. R-43479, Brenneria sp. R-43654, Brenneria sp. R-43655, Brenneria sp. R-43657, FRB 141, LMG 26270, LMG:26270, NCPPB 4484, strain R-43656
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