STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TRM5tRNA (guanine(37)-N1)-methyltransferase; Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding; Belongs to the TRM5 / TYW2 family. (437 aa)    
Predicted Functional Partners:
PIIN_04103
Related to probable RNA helicase MPH1.
    
 0.942
PIIN_00991
Probable mitochondrial carrier protein ARALAR1; Belongs to the mitochondrial carrier (TC 2.A.29) family.
 
      0.632
PIIN_04087
Probable Chromatin assembly factor 1 subunit c.
    
 0.601
PIIN_04159
Trafficking protein particle complex subunit; Belongs to the TRAPP small subunits family.
 
      0.595
PIIN_04853
Probable NPL4-nuclear protein localization factor and ER translocation component.
    
  0.534
PIIN_04755
Uncharacterized protein.
    
  0.526
PIIN_08830
Related to RFA2-DNA replication factor A, 36 kDa subunit.
    
  0.526
PIIN_02985
Uncharacterized protein.
    
  0.526
PIIN_07641
Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.
    
 0.522
PIIN_07203
Uncharacterized protein.
    
  0.520
Your Current Organism:
Serendipita indica
NCBI taxonomy Id: 1109443
Other names: Piriformospora indica DSM 11827, S. indica DSM 11827, Serendipita indica DSM 11827
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.