node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
PIIN_00248 | PIIN_00521 | G4T5G2 | G4U2P6 | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. | BPL/LPL catalytic domain-containing protein. | 0.910 |
PIIN_00248 | PIIN_01679 | G4T5G2 | G4T981 | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.932 |
PIIN_00248 | PIIN_08322 | G4T5G2 | G4TSS6 | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.979 |
PIIN_00521 | PIIN_00248 | G4U2P6 | G4T5G2 | BPL/LPL catalytic domain-containing protein. | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. | 0.910 |
PIIN_00521 | PIIN_01679 | G4U2P6 | G4T981 | BPL/LPL catalytic domain-containing protein. | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | 0.939 |
PIIN_00521 | PIIN_03316 | G4U2P6 | G4TDL2 | BPL/LPL catalytic domain-containing protein. | Related to NFU-1 protein (Iron homeostasis). | 0.518 |
PIIN_00521 | PIIN_03597 | G4U2P6 | G4TED5 | BPL/LPL catalytic domain-containing protein. | Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. | 0.439 |
PIIN_00521 | PIIN_04157 | G4U2P6 | G4TFW6 | BPL/LPL catalytic domain-containing protein. | Probable nitrilase (NIT3). | 0.592 |
PIIN_00521 | PIIN_06993 | G4U2P6 | G4TNZ5 | BPL/LPL catalytic domain-containing protein. | Probable NIT2-nitrilase. | 0.608 |
PIIN_00521 | PIIN_08322 | G4U2P6 | G4TSS6 | BPL/LPL catalytic domain-containing protein. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.992 |
PIIN_01679 | PIIN_00248 | G4T981 | G4T5G2 | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | U1 small nuclear ribonucleoprotein C; Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region. | 0.932 |
PIIN_01679 | PIIN_00521 | G4T981 | G4U2P6 | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | BPL/LPL catalytic domain-containing protein. | 0.939 |
PIIN_01679 | PIIN_03006 | G4T981 | G4TCR1 | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Probable ribosomal protein L13a; Belongs to the universal ribosomal protein uL13 family. | 0.816 |
PIIN_01679 | PIIN_03316 | G4T981 | G4TDL2 | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Related to NFU-1 protein (Iron homeostasis). | 0.633 |
PIIN_01679 | PIIN_03597 | G4T981 | G4TED5 | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Uroporphyrinogen decarboxylase; Belongs to the uroporphyrinogen decarboxylase family. | 0.612 |
PIIN_01679 | PIIN_04157 | G4T981 | G4TFW6 | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Probable nitrilase (NIT3). | 0.608 |
PIIN_01679 | PIIN_06235 | G4T981 | G4TLV8 | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Probable isopentenyl-diphosphate delta-isomerase. | 0.628 |
PIIN_01679 | PIIN_06993 | G4T981 | G4TNZ5 | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Probable NIT2-nitrilase. | 0.668 |
PIIN_01679 | PIIN_08322 | G4T981 | G4TSS6 | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Glycine cleavage system H protein; The H protein shuttles the methylamine group of glycine from the P protein to the T protein; Belongs to the GcvH family. | 0.991 |
PIIN_01679 | PIIN_08638 | G4T981 | G4TTP4 | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives. | Ribonucleoside-diphosphate reductase; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. | 0.613 |