PIIN_04411 protein (Serendipita indica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

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[Homology]

Score

PIIN_04411

Uncharacterized protein. (140 aa)

Predicted Functional Partners:

PIIN_08449

0.615

PIIN_08433

0.598

PIIN_00620

0.558

PIIN_07218

0.520

PIIN_00878

0.517

PIIN_00874

0.517

PIIN_08189

0.516

PIIN_02477

0.471

PIIN_00272

0.469

PIIN_00292

0.469

Your Current Organism:

Serendipita indica

NCBI taxonomy Id: 1109443
Other names: Piriformospora indica DSM 11827, S. indica DSM 11827, Serendipita indica DSM 11827

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PIIN_00272	PIIN_04411	G4T5L7	G4TGM5	Related to short-chain alcohol dehydrogenase.	Uncharacterized protein.	0.469
PIIN_00292	PIIN_04411	G4T5M6	G4TGM5	Uncharacterized protein.	Uncharacterized protein.	0.469
PIIN_00620	PIIN_04411	G4T687	G4TGM5	Aspartate aminotransferase.	Uncharacterized protein.	0.558
PIIN_00620	PIIN_08189	G4T687	G4TSE3	Aspartate aminotransferase.	Related to short-chain alcohol dehydrogenase.	0.462
PIIN_00620	PIIN_08449	G4T687	G4TT54	Aspartate aminotransferase.	Aspartate aminotransferase.	0.960
PIIN_00874	PIIN_04411	G4T6U7	G4TGM5	Related to steroid dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein.	0.517
PIIN_00874	PIIN_08189	G4T6U7	G4TSE3	Related to steroid dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Related to short-chain alcohol dehydrogenase.	0.490
PIIN_00878	PIIN_04411	G4T6R7	G4TGM5	Related to steroid dehydrogenase.	Uncharacterized protein.	0.517
PIIN_02477	PIIN_04411	G4TBC6	G4TGM5	Related to 1-acyldihydroxyacetone-phosphate reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	Uncharacterized protein.	0.471
PIIN_04411	PIIN_00272	G4TGM5	G4T5L7	Uncharacterized protein.	Related to short-chain alcohol dehydrogenase.	0.469
PIIN_04411	PIIN_00292	G4TGM5	G4T5M6	Uncharacterized protein.	Uncharacterized protein.	0.469
PIIN_04411	PIIN_00620	G4TGM5	G4T687	Uncharacterized protein.	Aspartate aminotransferase.	0.558
PIIN_04411	PIIN_00874	G4TGM5	G4T6U7	Uncharacterized protein.	Related to steroid dehydrogenase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.517
PIIN_04411	PIIN_00878	G4TGM5	G4T6R7	Uncharacterized protein.	Related to steroid dehydrogenase.	0.517
PIIN_04411	PIIN_02477	G4TGM5	G4TBC6	Uncharacterized protein.	Related to 1-acyldihydroxyacetone-phosphate reductase; Belongs to the short-chain dehydrogenases/reductases (SDR) family.	0.471
PIIN_04411	PIIN_07218	G4TGM5	G4TPM0	Uncharacterized protein.	Probable UDP-N-acetylglucosamine pyrophosphorylase.	0.520
PIIN_04411	PIIN_08189	G4TGM5	G4TSE3	Uncharacterized protein.	Related to short-chain alcohol dehydrogenase.	0.516
PIIN_04411	PIIN_08433	G4TGM5	G4TT37	Uncharacterized protein.	Uncharacterized protein.	0.598
PIIN_04411	PIIN_08449	G4TGM5	G4TT54	Uncharacterized protein.	Aspartate aminotransferase.	0.615
PIIN_07218	PIIN_04411	G4TPM0	G4TGM5	Probable UDP-N-acetylglucosamine pyrophosphorylase.	Uncharacterized protein.	0.520

page 1 of 2

Network Stats

number of nodes:

6

number of edges:

9

average node degree:

3

avg. local clustering coefficient:

0.8

expected number of edges:

8

PPI enrichment p-value:

0.412

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0000387

Spliceosomal snRNP assembly

4 of 30

2.45

2.86

3.49e-06

GO:0040031

snRNA modification

3 of 8

2.9

2.63

1.54e-05

GO:0008380

RNA splicing

6 of 351

1.55

1.92

9.26e-06

GO:0000398

mRNA splicing, via spliceosome

5 of 229

1.66

1.86

4.08e-05

GO:0016071

mRNA metabolic process

7 of 575

1.41

1.78

3.85e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0017069

snRNA binding

7 of 39

2.58

6.59

6.85e-14

GO:0017070

U6 snRNA binding

4 of 8

3.02

4.21

1.86e-08

GO:0003723

RNA binding

9 of 1208

1.19

1.57

1.37e-07

GO:0097322

7SK snRNA binding

2 of 5

2.92

1.46

0.0023

GO:1901363

Heterocyclic compound binding

10 of 6430

0.51

0.37

0.0105

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030532

Small nuclear ribonucleoprotein complex

5 of 59

2.25

3.5

8.06e-08

GO:0046540

U4/U6 x U5 tri-snRNP complex

4 of 32

2.42

3.19

6.88e-07

GO:0015030

Cajal body

4 of 36

2.37

3.17

6.88e-07

GO:0071005

U2-type precatalytic spliceosome

4 of 48

2.24

2.95

1.35e-06

GO:1990904

Ribonucleoprotein complex

7 of 598

1.39

1.89

6.88e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:19743

Regulation of protein localization to Cajal body, and U6 snRNA 3-end binding

4 of 6

3.15

4.14

2.82e-08

CL:18977

Small nuclear ribonucleoprotein complex, and snRNA binding

5 of 66

2.2

3.24

2.60e-07

CL:19047

Spliceosomal tri-snRNP complex assembly, and U4/U6 x U5 tri-snRNP complex

3 of 10

2.8

2.65

1.34e-05

CL:18979

Spliceosomal snRNP complex, and snRNA binding

4 of 60

2.15

2.46

1.20e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03040

Spliceosome

4 of 266

1.5

1.26

0.0011

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

5 of 391

1.43

1.31

0.00051

MAP-8953854

Metabolism of RNA

7 of 946

1.19

1.21

9.46e-05

MAP-72163

mRNA Splicing - Major Pathway

4 of 272

1.49

1.09

0.0034

MAP-72172

mRNA Splicing

4 of 296

1.45

1.06

0.0036

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1990904

Ribonucleoprotein complex

7 of 447

1.52

2.16

5.13e-07

GOCC:0005634

Nucleus

8 of 3501

0.68

0.43

0.0232

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