STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PIIN_05011DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (632 aa)    
Predicted Functional Partners:
PIIN_03556
3'-5' exonuclease domain-containing protein.
   
 0.999
PIIN_04103
Related to probable RNA helicase MPH1.
   
 0.999
PIIN_06810
Uncharacterized protein.
   
 0.999
PIIN_02747
DUF1767 domain-containing protein.
    
 0.997
PIIN_03778
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
   
 0.972
PIIN_06323
Related to QDE-3 QDE3 protein (Involved in gene silencing).
   
 0.972
PIIN_05582
Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
   
 0.969
PIIN_01729
Uncharacterized protein.
   
 0.968
PIIN_06794
Related to RAD1-component of the nucleotide excision repairosome.
    
 0.967
PIIN_08830
Related to RFA2-DNA replication factor A, 36 kDa subunit.
    
 0.965
Your Current Organism:
Serendipita indica
NCBI taxonomy Id: 1109443
Other names: Piriformospora indica DSM 11827, S. indica DSM 11827, Serendipita indica DSM 11827
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.