PIIN_07845 protein (Serendipita indica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

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[Homology]

Score

PIIN_07845

Uncharacterized protein. (643 aa)

Predicted Functional Partners:

PIIN_05140

0.779

PIIN_02621

0.735

PIIN_00919

0.653

PIIN_03865

0.653

PIIN_05912

0.653

PIIN_06206

0.653

PIIN_06902

0.653

PIIN_06904

0.653

PIIN_05448

0.575

PIIN_02624

0.549

Your Current Organism:

Serendipita indica

NCBI taxonomy Id: 1109443
Other names: Piriformospora indica DSM 11827, S. indica DSM 11827, Serendipita indica DSM 11827

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PIIN_00919	PIIN_02621	G4T6X6	G4TBR4	AB hydrolase-1 domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.693
PIIN_00919	PIIN_05140	G4T6X6	G4TIQ8	AB hydrolase-1 domain-containing protein.	Related to Neural Wiskott-Aldrich syndrome protein.	0.785
PIIN_00919	PIIN_05448	G4T6X6	G4TJJ8	AB hydrolase-1 domain-containing protein.	WH2 domain-containing protein.	0.408
PIIN_00919	PIIN_07845	G4T6X6	G4TRE9	AB hydrolase-1 domain-containing protein.	Uncharacterized protein.	0.653
PIIN_02621	PIIN_00919	G4TBR4	G4T6X6	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AB hydrolase-1 domain-containing protein.	0.693
PIIN_02621	PIIN_02624	G4TBR4	G4TBP4	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Related to Drebrin F.	0.468
PIIN_02621	PIIN_03865	G4TBR4	G4TF45	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AB hydrolase-1 domain-containing protein.	0.693
PIIN_02621	PIIN_05140	G4TBR4	G4TIQ8	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Related to Neural Wiskott-Aldrich syndrome protein.	0.890
PIIN_02621	PIIN_05912	G4TBR4	G4TKY4	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Uncharacterized protein.	0.693
PIIN_02621	PIIN_06206	G4TBR4	G4TLS9	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Uncharacterized protein.	0.693
PIIN_02621	PIIN_06902	G4TBR4	G4TNQ4	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	AB hydrolase-1 domain-containing protein.	0.693
PIIN_02621	PIIN_06904	G4TBR4	G4TNQ6	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Abhydrolase_4 domain-containing protein.	0.693
PIIN_02621	PIIN_07845	G4TBR4	G4TRE9	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	Uncharacterized protein.	0.735
PIIN_02624	PIIN_02621	G4TBP4	G4TBR4	Related to Drebrin F.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.468
PIIN_02624	PIIN_05140	G4TBP4	G4TIQ8	Related to Drebrin F.	Related to Neural Wiskott-Aldrich syndrome protein.	0.788
PIIN_02624	PIIN_05448	G4TBP4	G4TJJ8	Related to Drebrin F.	WH2 domain-containing protein.	0.512
PIIN_02624	PIIN_07845	G4TBP4	G4TRE9	Related to Drebrin F.	Uncharacterized protein.	0.549
PIIN_03865	PIIN_02621	G4TF45	G4TBR4	AB hydrolase-1 domain-containing protein.	Clathrin heavy chain; Clathrin is the major protein of the polyhedral coat of coated pits and vesicles; Belongs to the clathrin heavy chain family.	0.693
PIIN_03865	PIIN_05140	G4TF45	G4TIQ8	AB hydrolase-1 domain-containing protein.	Related to Neural Wiskott-Aldrich syndrome protein.	0.785
PIIN_03865	PIIN_05448	G4TF45	G4TJJ8	AB hydrolase-1 domain-containing protein.	WH2 domain-containing protein.	0.408

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Network Stats

number of nodes:

7

number of edges:

11

average node degree:

3.14

avg. local clustering coefficient:

0.833

expected number of edges:

6

PPI enrichment p-value:

0.0509

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0098609

Cell-cell adhesion

7 of 339

1.49

1.91

4.11e-06

GO:0007043

Cell-cell junction assembly

4 of 79

1.88

1.68

0.00035

GO:0016055

Wnt signaling pathway

5 of 174

1.63

1.62

0.00019

GO:0007155

Cell adhesion

8 of 592

1.3

1.6

4.11e-06

GO:0014068

Positive regulation of phosphatidylinositol 3-kinase signaling

3 of 37

2.08

1.4

0.0020

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045296

Cadherin binding

5 of 59

2.1

3.04

4.66e-07

GO:0050839

Cell adhesion molecule binding

7 of 226

1.66

2.62

8.90e-08

GO:0005001

Transmembrane receptor protein tyrosine phosphatase activity

2 of 3

3.0

1.35

0.0036

GO:0045294

Alpha-catenin binding

2 of 9

2.52

1.09

0.0100

GO:0042169

SH2 domain binding

2 of 24

2.09

0.76

0.0392

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005911

Cell-cell junction

7 of 307

1.53

2.22

3.55e-07

GO:0005912

Adherens junction

4 of 112

1.73

1.72

0.00016

GO:0030054

Cell junction

9 of 1317

1.01

1.1

4.42e-06

GO:0014704

Intercalated disc

2 of 17

2.24

1.05

0.0112

GO:0043235

Receptor complex

4 of 283

1.32

0.94

0.0051

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:23177

Catenin complex, and Armadillo/beta-catenin-like repeats

3 of 28

2.2

1.31

0.0034

CL:23185

Catenin complex

2 of 6

2.7

1.27

0.0049

CL:14634

Fz domain, and Positive regulation of fibroblast growth factor production

2 of 5

2.78

1.27

0.0049

CL:236

Mixed, incl. SH2 domain, and phosphatidylinositol-3-phosphate biosynthetic process

3 of 97

1.66

0.99

0.0093

CL:242

SH2 domain, and MET activates PTPN11

2 of 34

1.94

0.76

0.0366

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04520

Adherens junction

5 of 90

1.92

2.81

5.09e-07

map04310

Wnt signaling pathway

4 of 192

1.49

1.34

0.00059

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-5218920

VEGFR2 mediated vascular permeability

4 of 29

2.31

2.79

3.68e-06

MAP-418990

Adherens junctions interactions

4 of 39

2.19

2.62

6.07e-06

MAP-421270

Cell-cell junction organization

4 of 56

2.03

2.32

1.74e-05

MAP-1433559

Regulation of KIT signaling

3 of 15

2.48

2.29

5.04e-05

MAP-1500931

Cell-Cell communication

5 of 121

1.79

2.28

6.07e-06

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0393

Immunoglobulin domain

3 of 59

1.88

1.4

0.0015

KW-0675

Receptor

7 of 898

1.07

1.03

0.00015

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01392

Fz domain

2 of 3

3.0

1.16

0.0081

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00185

Armadillo/beta-catenin-like repeats

4 of 31

2.28

2.75

4.19e-06

SM00219

Tyrosine kinase, catalytic domain

4 of 79

1.88

1.96

7.24e-05

SM00408

Immunoglobulin C-2 Type

4 of 161

1.57

1.36

0.00076

SM00130

Kringle domain

2 of 14

2.33

1.1

0.0091

SM00194

Protein tyrosine phosphatase, catalytic domain

2 of 38

1.9

0.7

0.0467

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