PIIN_10714 protein (Serendipita indica) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Cooccurrence

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[Homology]

Score

PIIN_10714

Uncharacterized protein. (358 aa)

Predicted Functional Partners:

PIIN_02022

0.715

PIIN_03426

0.685

PIIN_01522

0.684

PIIN_00966

0.674

PIIN_05113

0.665

PIIN_00234

0.657

PIIN_00750

0.655

PIIN_00528

0.654

PIIN_03398

0.642

PIIN_04481

0.632

Your Current Organism:

Serendipita indica

NCBI taxonomy Id: 1109443
Other names: Piriformospora indica DSM 11827, S. indica DSM 11827, Serendipita indica DSM 11827

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
PIIN_00234	PIIN_00750	G4T5K1	G4T6E4	Uncharacterized protein.	Probable TATA-box-binding factor TBP.	0.786
PIIN_00234	PIIN_00966	G4T5K1	G4T799	Uncharacterized protein.	RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.813
PIIN_00234	PIIN_02022	G4T5K1	G4TA13	Uncharacterized protein.	TPR_REGION domain-containing protein.	0.999
PIIN_00234	PIIN_10714	G4T5K1	G4TZI3	Uncharacterized protein.	Uncharacterized protein.	0.657
PIIN_00528	PIIN_01522	G4U2Q2	G4T8P3	Probable ARP5-Actin-related protein; Belongs to the actin family.	Probable CHD1-transcriptional regulator.	0.818
PIIN_00528	PIIN_03398	G4U2Q2	G4TDW1	Probable ARP5-Actin-related protein; Belongs to the actin family.	Related to ACT1-actin; Belongs to the actin family.	0.981
PIIN_00528	PIIN_03426	G4U2Q2	G4U2I0	Probable ARP5-Actin-related protein; Belongs to the actin family.	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.	0.997
PIIN_00528	PIIN_05113	G4U2Q2	G4TIN4	Probable ARP5-Actin-related protein; Belongs to the actin family.	Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family.	0.991
PIIN_00528	PIIN_10714	G4U2Q2	G4TZI3	Probable ARP5-Actin-related protein; Belongs to the actin family.	Uncharacterized protein.	0.654
PIIN_00750	PIIN_00234	G4T6E4	G4T5K1	Probable TATA-box-binding factor TBP.	Uncharacterized protein.	0.786
PIIN_00750	PIIN_00966	G4T6E4	G4T799	Probable TATA-box-binding factor TBP.	RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	0.953
PIIN_00750	PIIN_01522	G4T6E4	G4T8P3	Probable TATA-box-binding factor TBP.	Probable CHD1-transcriptional regulator.	0.654
PIIN_00750	PIIN_02022	G4T6E4	G4TA13	Probable TATA-box-binding factor TBP.	TPR_REGION domain-containing protein.	0.851
PIIN_00750	PIIN_03398	G4T6E4	G4TDW1	Probable TATA-box-binding factor TBP.	Related to ACT1-actin; Belongs to the actin family.	0.708
PIIN_00750	PIIN_03426	G4T6E4	G4U2I0	Probable TATA-box-binding factor TBP.	RuvB-like helicase; DNA helicase participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes.	0.588
PIIN_00750	PIIN_04481	G4T6E4	G4TGV1	Probable TATA-box-binding factor TBP.	Related to TOA1-transcription factor TFIIA-L.	0.996
PIIN_00750	PIIN_05113	G4T6E4	G4TIN4	Probable TATA-box-binding factor TBP.	Actin-related protein 8; Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. Belongs to the actin family.	0.670
PIIN_00750	PIIN_10714	G4T6E4	G4TZI3	Probable TATA-box-binding factor TBP.	Uncharacterized protein.	0.655
PIIN_00966	PIIN_00234	G4T799	G4T5K1	RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Uncharacterized protein.	0.813
PIIN_00966	PIIN_00750	G4T799	G4T6E4	RNA polymerase III subunit C3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.	Probable TATA-box-binding factor TBP.	0.953

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

22

PPI enrichment p-value:

9.22e-10

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006412

Translation

11 of 298

1.49

3.05

1.60e-13

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003735

Structural constituent of ribosome

11 of 167

1.75

4.58

1.39e-16

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005761

Mitochondrial ribosome

10 of 70

2.08

6.48

1.13e-17

GO:0005762

Mitochondrial large ribosomal subunit

8 of 41

2.22

6.13

8.87e-15

GO:0005840

Ribosome

11 of 183

1.71

4.42

6.79e-17

GO:0044391

Ribosomal subunit

10 of 154

1.74

4.31

4.98e-15

GO:0098798

Mitochondrial protein-containing complex

10 of 177

1.68

3.98

1.09e-14

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:4871

Organellar large ribosomal subunit, and Ribosomal protein L23

10 of 18

2.67

10.54

1.79e-22

CL:4863

Organellar ribosome

11 of 53

2.24

8.49

5.45e-22

CL:4893

Organellar large ribosomal subunit

5 of 6

2.85

5.39

7.63e-11

CL:4872

Mixed, incl. Ribosomal protein L23, and Organellar large ribosomal subunit

5 of 10

2.63

4.87

4.40e-10

CL:4874

Mixed, incl. Ribosomal protein L23, and Translation protein SH3-like domain superfamily

3 of 5

2.71

2.67

1.15e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03010

Ribosome

11 of 187

1.7

4.39

4.60e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72766

Translation

9 of 253

1.48

2.58

4.66e-10

MAP-392499

Metabolism of proteins

9 of 907

0.92

0.93

1.76e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005762

Mitochondrial large ribosomal subunit

9 of 38

2.3

7.35

1.68e-17

GOCC:0005761

Mitochondrial ribosome

10 of 64

2.12

6.74

5.70e-18

GOCC:0044391

Ribosomal subunit

10 of 141

1.78

4.55

1.97e-15

GOCC:0098798

Mitochondrial protein complex

10 of 168

1.7

4.12

5.94e-15

GOCC:0005739

Mitochondrion

11 of 684

1.13

1.66

3.63e-11

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0689

Ribosomal protein

7 of 92

1.81

3.45

9.56e-10

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