STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
AMD87015.1Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (174 aa)    
Predicted Functional Partners:
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
  
  
 0.921
AMD87821.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.750
AMD88393.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.727
rbpA
Electron transporter; Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.
  
     0.717
AMD88081.1
dUTPase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.708
AMD88427.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
     0.678
gyrB
DNA topoisomerase IV subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
     
 0.663
AMD87706.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.660
AMD86732.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
  
     0.658
AMD87851.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
     0.658
Your Current Organism:
Actinomyces radicidentis
NCBI taxonomy Id: 111015
Other names: A. radicidentis, Actinomyces radicidentis Collins et al. 2001 emend. Nouioui et al. 2018, Actinomyces sp. CCUG 36733, Actinomyces sp. CCUG 36733T, CCUG 36733, CIP 106352, DSM 15433
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