STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nthUnannotated protein; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (245 aa)    
Predicted Functional Partners:
DIU77_02950
Unannotated protein.
 
 0.982
DIU77_06610
Unannotated protein.
   
   0.877
DIU77_06620
Unannotated protein.
  
    0.870
DIU77_06615
Unannotated protein.
     
 0.863
xth
Unannotated protein.
  
 0.838
xth-2
Unannotated protein.
  
 0.838
GCA_000427905_03286
Unannotated protein.
  
 
 0.778
DIU77_06000
Unannotated protein.
 
 
0.732
DIU77_02575
Unannotated protein.
  
 0.697
mutM
Unannotated protein; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.
   
  
 0.649
Your Current Organism:
Thermocrispum agreste
NCBI taxonomy Id: 1111738
Other names: T. agreste DSM 44070, Thermocrispum agreste DSM 44070, Thermocrispum agreste str. DSM 44070, Thermocrispum agreste strain DSM 44070
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.