node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Spaf_0644 | Spaf_0783 | Spaf_0644 | Spaf_0783 | L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.963 |
Spaf_0644 | ilvH | Spaf_0644 | Spaf_0510 | L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily. | Acetolactate synthase small subunit. | 0.834 |
Spaf_0644 | ldh | Spaf_0644 | Spaf_0976 | L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily. | L-lactate dehydrogenase 1; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. | 0.918 |
Spaf_0644 | leuA | Spaf_0644 | Spaf_0961 | L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.842 |
Spaf_0644 | leuB | Spaf_0644 | Spaf_0962 | L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.406 |
Spaf_0644 | leuC | Spaf_0644 | Spaf_0964 | L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily. | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.825 |
Spaf_0644 | leuD | Spaf_0644 | Spaf_0965 | L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.814 |
Spaf_0644 | poxL | Spaf_0644 | Spaf_1788 | L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily. | Pyruvate oxidase; Belongs to the TPP enzyme family. | 0.916 |
Spaf_0644 | ppdK | Spaf_0644 | Spaf_1269 | L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily. | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. | 0.918 |
Spaf_0783 | Spaf_0644 | Spaf_0783 | Spaf_0644 | Pyruvate kinase; Belongs to the pyruvate kinase family. | L-2-hydroxyisocaproate dehydrogenase; Belongs to the LDH/MDH superfamily. | 0.963 |
Spaf_0783 | ilvH | Spaf_0783 | Spaf_0510 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Acetolactate synthase small subunit. | 0.800 |
Spaf_0783 | ldh | Spaf_0783 | Spaf_0976 | Pyruvate kinase; Belongs to the pyruvate kinase family. | L-lactate dehydrogenase 1; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family. | 0.963 |
Spaf_0783 | leuA | Spaf_0783 | Spaf_0961 | Pyruvate kinase; Belongs to the pyruvate kinase family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.838 |
Spaf_0783 | leuC | Spaf_0783 | Spaf_0964 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Isopropylmalate isomerase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.819 |
Spaf_0783 | leuD | Spaf_0783 | Spaf_0965 | Pyruvate kinase; Belongs to the pyruvate kinase family. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.817 |
Spaf_0783 | poxL | Spaf_0783 | Spaf_1788 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Pyruvate oxidase; Belongs to the TPP enzyme family. | 0.924 |
Spaf_0783 | ppdK | Spaf_0783 | Spaf_1269 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Pyruvate phosphate dikinase; Belongs to the PEP-utilizing enzyme family. | 0.920 |
ilvC | ilvH | Spaf_0511 | Spaf_0510 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | Acetolactate synthase small subunit. | 0.998 |
ilvC | leuA | Spaf_0511 | Spaf_0961 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.909 |
ilvC | leuB | Spaf_0511 | Spaf_0962 | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.839 |