rsfS protein (Lactobacillus rossiae) - STRING interaction network

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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rsfS

Iojap family protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. (115 aa)

Predicted Functional Partners:

rplX

0.984

rplN

0.982

rplU

0.979

rplT

0.979

rplO

0.979

rplS

0.976

rplC

0.976

rplQ

0.976

rplM

0.976

rplK

0.971

Your Current Organism:

Lactobacillus rossiae

NCBI taxonomy Id: 1114972
Other names: L. rossiae DSM 15814, Lactobacillus rossiae DSM 15814, Lactobacillus rossiae str. DSM 15814, Lactobacillus rossiae strain DSM 15814

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
rplC	rplK	FD35_GL001997	FD35_GL001565	50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.	50s ribosomal protein l11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	0.999
rplC	rplM	FD35_GL001997	FD35_GL002029	50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.	50s ribosomal protein l13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.998
rplC	rplN	FD35_GL001997	FD35_GL002007	50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.	50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.	0.998
rplC	rplO	FD35_GL001997	FD35_GL002015	50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.	rplO protein; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.	0.999
rplC	rplQ	FD35_GL001997	FD35_GL002023	50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.	Ribosomal protein L17.	0.996
rplC	rplS	FD35_GL001997	FD35_GL000301	50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.	50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.	0.994
rplC	rplT	FD35_GL001997	FD35_GL000416	50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.	50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.994
rplC	rplU	FD35_GL001997	FD35_GL000355	50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.	Diaminopimelate epimerase; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.	0.994
rplC	rplX	FD35_GL001997	FD35_GL002008	50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.	50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.	0.998
rplC	rsfS	FD35_GL001997	FD35_GL000393	50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.	Iojap family protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.	0.976
rplK	rplC	FD35_GL001565	FD35_GL001997	50s ribosomal protein l11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.	0.999
rplK	rplM	FD35_GL001565	FD35_GL002029	50s ribosomal protein l11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	50s ribosomal protein l13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.995
rplK	rplN	FD35_GL001565	FD35_GL002007	50s ribosomal protein l11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	50S ribosomal protein L14; Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome; Belongs to the universal ribosomal protein uL14 family.	0.996
rplK	rplO	FD35_GL001565	FD35_GL002015	50s ribosomal protein l11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	rplO protein; Binds to the 23S rRNA; Belongs to the universal ribosomal protein uL15 family.	0.995
rplK	rplQ	FD35_GL001565	FD35_GL002023	50s ribosomal protein l11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	Ribosomal protein L17.	0.995
rplK	rplS	FD35_GL001565	FD35_GL000301	50s ribosomal protein l11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	50S ribosomal protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.	0.995
rplK	rplT	FD35_GL001565	FD35_GL000416	50s ribosomal protein l11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.994
rplK	rplU	FD35_GL001565	FD35_GL000355	50s ribosomal protein l11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	Diaminopimelate epimerase; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.	0.994
rplK	rplX	FD35_GL001565	FD35_GL002008	50s ribosomal protein l11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	50S ribosomal protein L24; One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.	0.996
rplK	rsfS	FD35_GL001565	FD35_GL000393	50s ribosomal protein l11; Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.	Iojap family protein; Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.	0.971

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Network Stats

number of nodes:

11

number of edges:

23

average node degree:

4.18

avg. local clustering coefficient:

0.735

expected number of edges:

10

PPI enrichment p-value:

0.000502

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015986

Proton motive force-driven ATP synthesis

7 of 22

2.68

6.72

7.27e-14

GO:1902600

Proton transmembrane transport

7 of 88

2.07

4.44

6.34e-11

GO:0042776

Proton motive force-driven mitochondrial ATP synthesis

4 of 12

2.7

3.81

7.16e-08

GO:0061469

Regulation of type B pancreatic cell proliferation

2 of 9

2.52

1.33

0.0036

GO:0006796

Phosphate-containing compound metabolic process

10 of 1477

1.0

1.19

1.27e-07

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0015078

Proton transmembrane transporter activity

7 of 89

2.07

4.29

1.62e-10

GO:0046933

Proton-transporting ATP synthase activity, rotational mechanism

4 of 10

2.78

3.68

1.46e-07

GO:0043027

Cysteine-type endopeptidase inhibitor activity involved in apoptotic process

2 of 10

2.48

1.19

0.0065

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005753

Mitochondrial proton-transporting ATP synthase complex

7 of 18

2.76

7.47

3.25e-15

GO:0032133

Chromosome passenger complex

4 of 7

2.93

4.35

9.43e-09

GO:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

3 of 5

2.95

3.16

1.64e-06

GO:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

3 of 12

2.57

2.65

1.11e-05

GO:0000275

Mitochondrial proton-transporting ATP synthase complex, catalytic sector F(1)

2 of 3

3.0

1.98

0.00026

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:22668

Mitochondrial proton-transporting ATP synthase complex

7 of 13

2.91

7.82

1.38e-15

CL:22670

CF(1), and Formation of ATP by chemiosmotic coupling

5 of 6

3.09

5.83

1.85e-11

CL:8092

Mixed, incl. Spindle midzone, and Kinesin motor, catalytic domain. ATPase.

4 of 43

2.14

2.58

6.61e-06

CL:8120

Chromosome passenger complex, and Activation of NIMA Kinases NEK9, NEK6, NEK7

3 of 12

2.57

2.43

2.92e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

8 of 166

1.86

4.18

4.21e-12

map01100

Metabolic pathways

8 of 2460

0.69

0.52

0.0027

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-163210

Formation of ATP by chemiosmotic coupling

7 of 18

2.76

7.43

4.12e-15

MAP-8949613

Cristae formation

7 of 27

2.59

6.82

2.30e-14

MAP-1592230

Mitochondrial biogenesis

7 of 50

2.32

5.69

7.50e-13

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

7 of 120

1.94

3.97

1.87e-10

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

7 of 178

1.77

3.26

2.17e-09

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000862

Heart ventricle

3 of 40

2.05

2.27

2.44e-05

BTO:0000562

Heart

4 of 233

1.41

1.53

5.79e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0045259

Proton-transporting ATP synthase complex

7 of 29

2.56

6.57

6.48e-14

GOCC:0005753

Mitochondrial proton-transporting ATP synthase complex

4 of 11

2.73

3.81

7.47e-08

GOCC:0045261

Proton-transporting ATP synthase complex, catalytic core F(1)

4 of 14

2.63

3.66

1.25e-07

GOCC:0032133

Chromosome passenger complex

3 of 4

3.05

3.13

1.97e-06

GOCC:0045263

Proton-transporting ATP synthase complex, coupling factor F(o)

3 of 15

2.48

2.38

3.43e-05

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0375

Hydrogen ion transport

3 of 26

2.24

1.85

0.00029

KW-0139

CF(1)

2 of 4

2.87

1.63

0.0011

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00238

Baculoviral inhibition of apoptosis protein repeat

2 of 7

2.63

1.08

0.0109

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