node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ERG54159.1 | ERG55048.1 | PSPO_07614 | PSPO_03750 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Carbon-nitrogen ligase; COG0212 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | 0.915 |
ERG54159.1 | folA | PSPO_07614 | PSPO_02375 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.919 |
ERG54159.1 | folD | PSPO_07614 | PSPO_10529 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Bifunctional: 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.968 |
ERG54159.1 | glyA | PSPO_07614 | PSPO_10904 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.915 |
ERG54159.1 | metH | PSPO_07614 | PSPO_03540 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; COG1410 Methionine synthase I, cobalamin-binding domain. | 0.914 |
ERG54159.1 | purD | PSPO_07614 | PSPO_11857 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Phosphoribosylglycinamide synthetase; COG0151 Phosphoribosylamine-glycine ligase; Belongs to the GARS family. | 0.930 |
ERG54159.1 | purH | PSPO_07614 | PSPO_11867 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.931 |
ERG54159.1 | purL | PSPO_07614 | PSPO_21139 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.935 |
ERG54159.1 | purN | PSPO_07614 | PSPO_17481 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.926 |
ERG54159.1 | purU | PSPO_07614 | PSPO_03475 | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | Formyltetrahydrofolate hydrolase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.919 |
ERG55048.1 | ERG54159.1 | PSPO_03750 | PSPO_07614 | Carbon-nitrogen ligase; COG0212 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | 0.915 |
ERG55048.1 | folD | PSPO_03750 | PSPO_10529 | Carbon-nitrogen ligase; COG0212 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Bifunctional: 5,10-methylene-tetrahydrofolate dehydrogenase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.953 |
ERG55048.1 | glyA | PSPO_03750 | PSPO_10904 | Carbon-nitrogen ligase; COG0212 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.460 |
ERG55048.1 | purN | PSPO_03750 | PSPO_17481 | Carbon-nitrogen ligase; COG0212 5-formyltetrahydrofolate cyclo-ligase; Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.937 |
folA | ERG54159.1 | PSPO_02375 | PSPO_07614 | Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | COG0299 Folate-dependent phosphoribosylglycinamide formyltransferase PurN. | 0.919 |
folA | glyA | PSPO_02375 | PSPO_10904 | Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.923 |
folA | metH | PSPO_02375 | PSPO_03540 | Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | B12-dependent homocysteine-N5-methyltetrahydrofolate transmethylase; COG1410 Methionine synthase I, cobalamin-binding domain. | 0.913 |
folA | purH | PSPO_02375 | PSPO_11867 | Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; COG0138 AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful). | 0.918 |
folA | purN | PSPO_02375 | PSPO_17481 | Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.917 |
folA | purU | PSPO_02375 | PSPO_03475 | Dihydrofolate reductase type I, trimethoprim resistance; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formyltetrahydrofolate hydrolase; Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). | 0.912 |