Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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gene neighborhood
gene co-occurrence
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AFY37103.1PFAM: Response regulator receiver domain; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR001789; KEGG: syp:SYNPCC7002_A2602 two-component response regulator; PFAM: Signal transduction response regulator, receiver domain; SMART: Signal transduction response regulator, receiver domain; SPTR: Two-component response regulator. (401 aa)    
Predicted Functional Partners:
AFY37107.1
PFAM: HAMP domain; Methyl-accepting chemotaxis protein (MCP) signaling domain; COGs: COG0840 Methyl-accepting chemotaxis protein; InterPro IPR003660:IPR004089; KEGG: syp:SYNPCC7002_A2599 methyl-accepting chemotaxis like protein; PFAM: Chemotaxis methyl-accepting receptor, signalling; HAMP linker domain; SMART: Chemotaxis methyl-accepting receptor, signalling; HAMP linker domain; SPTR: Methyl-accepting chemotaxis like protein.
 
 0.960
AFY37106.1
PFAM: CheW-like domain; COGs: COG0835 Chemotaxis signal transduction protein; InterPro IPR002545; KEGG: syp:SYNPCC7002_A2600 CheW-like domain-containing protein; PFAM: CheW-like protein; SMART: CheW-like protein; SPTR: CheW-like domain containing protein.
  
  0.958
AFY38882.1
PFAM: HAMP domain; Methyl-accepting chemotaxis protein (MCP) signaling domain; COGs: COG0840 Methyl-accepting chemotaxis protein; InterPro IPR003660:IPR004089; KEGG: syp:SYNPCC7002_A1372 methyl-accepting chemotaxis protein; PFAM: Chemotaxis methyl-accepting receptor, signalling; HAMP linker domain; SMART: Chemotaxis methyl-accepting receptor, signalling; HAMP linker domain; SPTR: Methyl-accepting chemotaxis protein.
  
  0.936
AFY38879.1
PFAM: Response regulator receiver domain; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789; KEGG: syp:SYNPCC7002_A1375 putative two component system response regulator; PFAM: Signal transduction response regulator, receiver domain; SMART: Signal transduction response regulator, receiver domain; SPTR: Putative two component system response regulator.
  
 
 
0.915
AFY37104.1
PFAM: Response regulator receiver domain; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR001789; KEGG: syp:SYNPCC7002_A2602 two-component response regulator; PFAM: Signal transduction response regulator, receiver domain; SMART: Signal transduction response regulator, receiver domain; SPTR: Two-component response regulator.
  
  
 
0.902
AFY37536.1
Multi-sensor signal transduction histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG2205 Osmosensitive K+ channel histidine kinase; InterProIPR001789:IPR000014:IPR003661:IPR003594:IPR 013767; KEGG: gvi:gll0634 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; Signal transduction response regulator, receiver domain; PAS f [...]
 
 
 0.748
AFY36567.1
PFAM: Response regulator receiver domain; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR001789; KEGG: cyt:cce_4289 two-component hybrid sensor and regulator; PFAM: Signal transduction response regulator, receiver domain; SMART: Signal transduction response regulator, receiver domain; SPTR: Multi-sensor Hybrid Histidine Kinase; manually curated.
  
   0.714
sasA
Histidine kinase; May be involved in signal transduction. Participates in the KaiABC clock protein complex, which constitutes the main circadian regulator in cyanobacteria, via its interaction with KaiC. Required for robustness of the circadian rhythm of gene expression and is involved in clock outputs.
  
 
   0.682
AFY37922.1
Response regulator receiver modulated CheB methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
  
 
 0.668
AFY37973.1
Adenylate/guanylate cyclase with integral membrane sensor; PFAM: Adenylate and Guanylate cyclase catalytic domain; HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; COGs: COG0642 Signal transduction histidine kinase; InterProIPR003660:IPR003661:IPR003594:IPR001789:IPR 013767:IPR001054:IPR000014; KEGG: ter:Tery_2729 adenylate/guanylate cyclase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; HAMP linker dom [...]
  
 
 0.660
Your Current Organism:
Leptolyngbya sp. PCC7376
NCBI taxonomy Id: 111781
Other names: Enugrolinea bermudensis PCC 7376, L. sp. PCC 7376, Leptolyngbya PCC7376, Leptolyngbya sp. PCC 7376
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