Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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AFY37395.1Integral membrane sensor signal transduction histidine kinase; PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR003660:IPR003661:IPR003594; KEGG: naz:Aazo_2222 integral membrane sensor signal transduction histidine kinase; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; HAMP linker domain; SMART: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dim [...] (491 aa)    
Predicted Functional Partners:
AFY37394.1
Two component transcriptional regulator, winged helix family; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789:IPR001867; KEGG: ava:Ava_3453 two component transcriptional regulator; PFAM: Signal transduction response regulator, receiver domain; Signal transduction response regulator, C-terminal; SMART: Signal transduction response regulator, receiver domain; SPTR: Two component transcriptional regulator.
 
   0.953
AFY37666.1
Two component transcriptional regulator, winged helix family; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789:IPR001867; KEGG: syp:SYNPCC7002_A0139 OmpR family two-component response regulator; PFAM: Signal transduction response regulator, receiver domain; Signal transduction response regulator, C-terminal; SMART: Signal transduction response regulator, receiver domain; SPTR: Two-component system response regulat [...]
  
   0.716
AFY38734.1
Two component transcriptional regulator, LuxR family; PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family; COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterPro IPR001789:IPR000792; KEGG: syp:SYNPCC7002_A2033 two-component response regulator; PFAM: Signal transduction response regulator, receiver domain; Transcription regulator LuxR, C-terminal; SMART: Signal transduction response regulator, receiver domain; Transcription regulator LuxR, C-terminal; SPTR: Two-component response regulator.
  
 
   0.716
AFY36836.1
Two component transcriptional regulator, winged helix family; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789:IPR001867; KEGG: npu:Npun_R3793 two component transcriptional regulator; PFAM: Signal transduction response regulator, receiver domain; Signal transduction response regulator, C-terminal; SMART: Signal transduction response regulator, receiver domain; SPTR: Two component transcriptional regulator, winged [...]
  
   0.715
AFY37361.1
Two component transcriptional regulator, winged helix family; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789:IPR001867; KEGG: syp:SYNPCC7002_A0937 two-component response regulator; PFAM: Signal transduction response regulator, receiver domain; Signal transduction response regulator, C-terminal; SMART: Signal transduction response regulator, receiver domain; SPTR: Two-component response regulator.
  
   0.667
AFY37105.1
PFAM: Response regulator receiver domain; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789; KEGG: syp:SYNPCC7002_A2601 CheY subfamily protein; PFAM: Signal transduction response regulator, receiver domain; SMART: Signal transduction response regulator, receiver domain; SPTR: CheY subfamily protein.
  
   0.664
AFY38880.1
PFAM: Response regulator receiver domain; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789; KEGG: syp:SYNPCC7002_A1374 two-component system response regulator; PFAM: Signal transduction response regulator, receiver domain; SMART: Signal transduction response regulator, receiver domain; SPTR: Two-component system response regulator.
  
   0.662
AFY37396.1
Methyltransferase type 11; PFAM: ubiE/COQ5 methyltransferase family; COGs: COG2226 Methylase involved in ubiquinone/menaquinone biosynthesis; InterPro IPR013216; KEGG: cyn:Cyan7425_2262 methyltransferase type 11; PFAM: Methyltransferase type 11; SPTR: Methyltransferase type 11.
       0.661
AFY37431.1
Two component transcriptional regulator, winged helix family; PFAM: Response regulator receiver domain; Transcriptional regulatory protein, C terminal; COGs: COG0745 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain; InterPro IPR001789:IPR001867; KEGG: ava:Ava_0615 two component transcriptional regulator; PFAM: Signal transduction response regulator, receiver domain; Signal transduction response regulator, C-terminal; SMART: Signal transduction response regulator, receiver domain; SPTR: Response regulator receiver domain protein.
  
   0.631
AFY39243.1
PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; GAF domain; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; COGs: COG0642 Signal transduction histidine kinase; InterPro IPR001789:IPR003018:IPR003661:IPR003594; KEGG: syp:SYNPCC7002_A0689 two-component hybrid sensor and regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; GAF; Signal transduction response regulator, receiver domain; SMART: ATPase-like, ATP-binding domain; GAF; Signal transduction response regulato [...]
 
 
0.622
Your Current Organism:
Leptolyngbya sp. PCC7376
NCBI taxonomy Id: 111781
Other names: Enugrolinea bermudensis PCC 7376, L. sp. PCC 7376, Leptolyngbya PCC7376, Leptolyngbya sp. PCC 7376
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