STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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[Homology]
Score
AFY37641.1Integral membrane sensor signal transduction histidine kinase; PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; His Kinase A (phosphoacceptor) domain; COGs: COG4191 Signal transduction histidine kinase regulating C4-dicarboxylate transport system; InterPro IPR003594; KEGG: npu:Npun_F0342 multi-sensor signal transduction multi-kinase; PFAM: ATPase-like, ATP-binding domain; SMART: ATPase-like, ATP-binding domain; SPTR: Multi-sensor signal transduction multi-kinase. (571 aa)    
Predicted Functional Partners:
AFY40193.1
Response regulator receiver modulated GAF sensor protein; PFAM: Response regulator receiver domain; COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789:IPR003018; KEGG: npu:Npun_R4435 response regulator receiver modulated GAF sensor protein; PFAM: Signal transduction response regulator, receiver domain; GAF; SMART: Signal transduction response regulator, receiver domain; SPTR: Putative GAF sensor protein.
  
 
 
 0.787
AFY37770.1
Protein serine/threonine phosphatase with GAF(s) sensor(s); PFAM: GAF domain; Response regulator receiver domain; Stage II sporulation protein E (SpoIIE); COGs: COG2208 Serine phosphatase RsbU regulator of sigma subunit; InterPro IPR001789:IPR003018:IPR001932:IPR010822; KEGG: npu:Npun_R5135 response regulator receiver modulated serine phosphatase with GAF sensor; PFAM: Sporulation stage II, protein E C-terminal; Signal transduction response regulator, receiver domain; GAF; SMART: Protein phosphatase 2C-related; Signal transduction response regulator, receiver domain; GAF; SPTR: Stage I [...]
 
 
 
 0.716
AFY40437.1
Adenylate/guanylate cyclase with GAF sensor(s); PFAM: Adenylate and Guanylate cyclase catalytic domain; Response regulator receiver domain; GAF domain; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR001789:IPR003018:IPR001054; KEGG: cyp:PCC8801_1264 adenylate/guanylate cyclase with GAF sensor(s); PFAM: Signal transduction response regulator, receiver domain; GAF; Adenylyl cyclase class-3/4/guanylyl cyclase; SMART: Signal transduction response regulator, receiver domain; GAF; Adenylyl cyclase class-3/4/guanylyl cyclase; SPTR: Adenylate/guanylate [...]
 
 
 
 0.620
AFY37922.1
Response regulator receiver modulated CheB methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
 
 
 0.528
AFY36740.1
PFAM: HAMP domain; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Response regulator receiver domain; His Kinase A (phosphoacceptor) domain; PAS fold; TIGRFAM: PAS domain S-box; COGs: COG0642 Signal transduction histidine kinase; InterProIPR000014:IPR001610:IPR003661:IPR003594:IPR 001789:IPR003660:IPR013655; KEGG: syp:SYNPCC7002_A0996 two-component hybrid sensor kinase/response regulator; PFAM: ATPase-like, ATP-binding domain; Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain; PAS fold-3; HAMP linker domain; Signal transduction response reg [...]
  
 
 0.432
AFY37640.1
PFAM: Trypsin; Hsp70 protein; COGs: COG0443 Molecular chaperone; InterPro IPR019734:IPR013126; KEGG: rci:LRC471 molecular chaperone DnaK; PFAM: Heat shock protein 70; SPTR: Chaperone protein dnaK.
  
    0.412
Your Current Organism:
Leptolyngbya sp. PCC7376
NCBI taxonomy Id: 111781
Other names: Enugrolinea bermudensis PCC 7376, L. sp. PCC 7376, Leptolyngbya PCC7376, Leptolyngbya sp. PCC 7376
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