STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHI37974.1dCMP deaminase. (133 aa)    
Predicted Functional Partners:
thyA
Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.
  
 
 0.938
tdk
Thymidine kinase.
  
 
 0.924
SHI50973.1
Deoxyadenosine/deoxycytidine kinase.
   
 0.919
cmk
Cytidylate kinase.
    
  0.902
xerC
Integrase/recombinase XerD; Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC- XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids.
       0.789
SHI38033.1
NUDIX domain-containing protein.
       0.781
SHI30318.1
Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
  
 
 0.568
SHI93614.1
Peptidyl-dipeptidase Dcp.
 
    0.537
SHI37942.1
enoyl-CoA hydratase; Belongs to the enoyl-CoA hydratase/isomerase family.
       0.513
SHI77767.1
ABC-type branched-chain amino acid transport system, substrate-binding protein.
    
  0.465
Your Current Organism:
Cruoricaptor ignavus
NCBI taxonomy Id: 1118202
Other names: C. ignavus, CCUG 62025, Cruoricaptor ignavus Yassin et al. 2013, DSM 25479, Flavobacteriaceae bacterium IMMIB L-12475, IMMIB L-12475
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