H257_09969 protein (Aphanomyces astaci) - STRING interaction network

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query proteins and first shell of interactors

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second shell of interactors

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filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

H257_09969

Uncharacterized protein. (893 aa)

Predicted Functional Partners:

H257_10015

0.691

H257_13610

0.635

H257_05696

0.625

B5M09_008085

0.598

B5M09_013521

0.572

H257_08112

0.572

H257_00181

0.572

H257_08205

0.550

H257_16388

0.521

B5M09_004925

0.509

Your Current Organism:

Aphanomyces astaci

NCBI taxonomy Id: 112090
Other names: A. astaci

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B5M09_004925	B5M09_008085	W4FWK7	W4GEL6	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Autophagy-related protein.	0.724
B5M09_004925	B5M09_013521	W4FWK7	W4FNL4	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Serine/threonine protein kinase.	0.785
B5M09_004925	H257_00181	W4FWK7	W4HC01	UBIQUITIN_CONJUGAT_2 domain-containing protein.	PLK protein kinase.	0.785
B5M09_004925	H257_08112	W4FWK7	W4GG36	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Serine/threonine-protein kinase PLK.	0.785
B5M09_004925	H257_08205	W4FWK7	W4GFX7	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Uncharacterized protein.	0.636
B5M09_004925	H257_09969	W4FWK7	W4G8M0	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Uncharacterized protein.	0.509
B5M09_004925	H257_13610	W4FWK7	W4FTH9	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Uncharacterized protein.	0.767
B5M09_004925	H257_16388	W4FWK7	W4FIT9	UBIQUITIN_CONJUGAT_2 domain-containing protein.	Peptidase C50 domain-containing protein.	0.893
B5M09_008085	B5M09_004925	W4GEL6	W4FWK7	Autophagy-related protein.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.724
B5M09_008085	H257_09969	W4GEL6	W4G8M0	Autophagy-related protein.	Uncharacterized protein.	0.598
B5M09_013521	B5M09_004925	W4FNL4	W4FWK7	Serine/threonine protein kinase.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.785
B5M09_013521	H257_05696	W4FNL4	W4GP32	Serine/threonine protein kinase.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.884
B5M09_013521	H257_09969	W4FNL4	W4G8M0	Serine/threonine protein kinase.	Uncharacterized protein.	0.572
B5M09_013521	H257_16388	W4FNL4	W4FIT9	Serine/threonine protein kinase.	Peptidase C50 domain-containing protein.	0.961
H257_00181	B5M09_004925	W4HC01	W4FWK7	PLK protein kinase.	UBIQUITIN_CONJUGAT_2 domain-containing protein.	0.785
H257_00181	H257_05696	W4HC01	W4GP32	PLK protein kinase.	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	0.884
H257_00181	H257_09969	W4HC01	W4G8M0	PLK protein kinase.	Uncharacterized protein.	0.572
H257_00181	H257_16388	W4HC01	W4FIT9	PLK protein kinase.	Peptidase C50 domain-containing protein.	0.961
H257_05696	B5M09_013521	W4GP32	W4FNL4	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	Serine/threonine protein kinase.	0.884
H257_05696	H257_00181	W4GP32	W4HC01	Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B; Belongs to the phosphatase 2A regulatory subunit B family.	PLK protein kinase.	0.884

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

16

average node degree:

2.91

avg. local clustering coefficient:

0.861

expected number of edges:

12

PPI enrichment p-value:

0.164

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070286

Axonemal dynein complex assembly

6 of 32

2.55

5.21

6.00e-11

GO:0003341

Cilium movement

7 of 143

1.97

3.85

7.51e-10

GO:0007018

Microtubule-based movement

9 of 337

1.71

3.45

4.91e-11

GO:0044782

Cilium organization

8 of 320

1.68

3.08

1.17e-09

GO:0007017

Microtubule-based process

10 of 725

1.42

2.48

1.06e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0045503

Dynein light chain binding

4 of 9

2.93

3.83

8.86e-08

GO:0045504

Dynein heavy chain binding

4 of 13

2.77

3.67

1.47e-07

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005858

Axonemal dynein complex

4 of 15

2.7

3.77

8.49e-08

GO:0030286

Dynein complex

5 of 57

2.22

3.46

8.49e-08

GO:0005875

Microtubule associated complex

6 of 144

1.9

3.05

8.49e-08

GO:0032838

Plasma membrane bounded cell projection cytoplasm

6 of 201

1.75

2.73

1.49e-07

GO:0005930

Axoneme

5 of 140

1.83

2.54

1.47e-06

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:33101214

(2020) The Role of Genetics and Oxidative Stress in the Etiology of Male Infertility-A Unifying Hypothesis?

8 of 70

2.34

5.89

2.82e-13

PMID:34768622

(2021) A Study on the Genetics of Primary Ciliary Dyskinesia.

4 of 16

2.68

2.79

6.67e-06

PMID:36714566

(2022) Deleterious variants in TAF7L cause human oligoasthenoteratozoospermia and its impairing histone to protamine exchange inducing reduced in vitro fertilization.

3 of 27

2.32

1.09

0.0097

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17689

Mixed, incl. Dynein complex, and Dynactin complex

8 of 118

2.11

5.13

1.04e-12

CL:17827

Mixed, incl. Axonemal dynein complex assembly, and Dynein heavy chain 3, AAA+ lid domain

6 of 42

2.43

4.96

1.12e-10

CL:17830

Axonemal dynein complex assembly, and Dynein heavy chain, tail

4 of 20

2.58

3.33

5.05e-07

CL:17831

Axonemal dynein complex assembly, and Radial spokehead-like protein

3 of 13

2.64

2.34

4.65e-05

CL:17833

Mixed, incl. Outer dynein arm, and Sperm tail

2 of 7

2.73

1.22

0.0060

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0001363

Testis

7 of 793

1.22

1.33

3.48e-05

BTO:0000082

Male reproductive system

8 of 1145

1.12

1.2

2.45e-05

BTO:0000522

Gland

8 of 4071

0.57

0.35

0.0402

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005858

Axonemal dynein complex

5 of 19

2.7

4.73

1.06e-09

GOCC:0005930

Axoneme

6 of 101

2.05

3.7

6.37e-09

GOCC:0005875

Microtubule associated complex

6 of 112

2.01

3.62

6.37e-09

GOCC:0005929

Cilium

7 of 422

1.5

2.26

1.01e-07

GOCC:0036156

Inner dynein arm

2 of 6

2.8

1.65

0.00098

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00320

WD40 repeats

4 of 271

1.45

0.95

0.0073

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