GCA_000429145_01694 protein (Aestuariibacter salexigens)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

GCA_000429145_01694

Unannotated protein. (286 aa)

Predicted Functional Partners:

GCA_000429145_00757

0.940

GCA_000429145_01795

0.808

GCA_000429145_00833

0.793

GCA_000429145_00166

0.782

GCA_000429145_02089

0.782

GCA_000429145_01797

0.742

GCA_000429145_00156

0.706

GCA_000429145_00442

0.706

GCA_000429145_00443

0.706

GCA_000429145_00648

0.706

Your Current Organism:

Aestuariibacter salexigens

NCBI taxonomy Id: 1120953
Other names: A. salexigens DSM 15300, Aestuariibacter salexigens DSM 15300

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
GCA_000429145_00156	GCA_000429145_00833	Unannotated protein.	Unannotated protein.	0.401
GCA_000429145_00156	GCA_000429145_01694	Unannotated protein.	Unannotated protein.	0.706
GCA_000429145_00156	GCA_000429145_01795	Unannotated protein.	Unannotated protein.	0.674
GCA_000429145_00156	GCA_000429145_01797	Unannotated protein.	Unannotated protein.	0.736
GCA_000429145_00166	GCA_000429145_00757	Unannotated protein.	Unannotated protein.	0.751
GCA_000429145_00166	GCA_000429145_00833	Unannotated protein.	Unannotated protein.	0.995
GCA_000429145_00166	GCA_000429145_01694	Unannotated protein.	Unannotated protein.	0.782
GCA_000429145_00166	GCA_000429145_01795	Unannotated protein.	Unannotated protein.	0.839
GCA_000429145_00166	GCA_000429145_01797	Unannotated protein.	Unannotated protein.	0.400
GCA_000429145_00442	GCA_000429145_00443	Unannotated protein.	Unannotated protein.	0.735
GCA_000429145_00442	GCA_000429145_00833	Unannotated protein.	Unannotated protein.	0.401
GCA_000429145_00442	GCA_000429145_01694	Unannotated protein.	Unannotated protein.	0.706
GCA_000429145_00442	GCA_000429145_01795	Unannotated protein.	Unannotated protein.	0.674
GCA_000429145_00442	GCA_000429145_01797	Unannotated protein.	Unannotated protein.	0.736
GCA_000429145_00443	GCA_000429145_00442	Unannotated protein.	Unannotated protein.	0.735
GCA_000429145_00443	GCA_000429145_00833	Unannotated protein.	Unannotated protein.	0.401
GCA_000429145_00443	GCA_000429145_01694	Unannotated protein.	Unannotated protein.	0.706
GCA_000429145_00443	GCA_000429145_01795	Unannotated protein.	Unannotated protein.	0.674
GCA_000429145_00443	GCA_000429145_01797	Unannotated protein.	Unannotated protein.	0.736
GCA_000429145_00648	GCA_000429145_00833	Unannotated protein.	Unannotated protein.	0.401

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.859

expected number of edges:

23

PPI enrichment p-value:

0.21

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0042254

Ribosome biogenesis

11 of 265

1.96

5.98

3.12e-18

GO:0006364

rRNA processing

9 of 178

2.04

5.49

1.29e-14

GO:0030490

Maturation of SSU-rRNA

3 of 35

2.27

1.87

0.00027

GO:0000462

Maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)

2 of 24

2.26

0.87

0.0252

GO:0000154

rRNA modification

2 of 32

2.13

0.75

0.0413

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0030515

snoRNA binding

4 of 29

2.48

3.09

1.31e-06

GO:0003723

RNA binding

11 of 1204

1.3

2.17

1.45e-11

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032040

Small-subunit processome

8 of 39

2.65

8.4

1.20e-17

GO:0030684

Preribosome

9 of 69

2.45

8.23

1.75e-18

GO:0005730

Nucleolus

11 of 549

1.64

3.98

4.30e-16

GO:0005732

sno(s)RNA-containing ribonucleoprotein complex

4 of 26

2.53

3.68

9.17e-08

GO:0030686

90S preribosome

4 of 28

2.49

3.62

1.08e-07

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:15115

Small-subunit processome, and Positive regulation of rRNA processing

11 of 35

2.84

13.24

1.72e-27

CL:15117

Small-subunit processome, and Positive regulation of rRNA processing

10 of 30

2.86

12.28

3.74e-25

CL:15120

Small-subunit processome, and AARP2CN (NUC121) domain

7 of 23

2.82

8.09

2.40e-16

CL:15121

Small-subunit processome

6 of 17

2.89

7.01

5.36e-14

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03008

Ribosome biogenesis in eukaryotes

9 of 119

2.22

6.95

2.80e-17

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-8868773

rRNA processing in the nucleus and cytosol

11 of 217

2.04

6.81

7.49e-20

MAP-72312

rRNA processing

11 of 229

2.02

6.68

7.49e-20

MAP-6791226

Major pathway of rRNA processing in the nucleolus and cytosol

10 of 212

2.01

6.07

2.28e-17

MAP-8953854

Metabolism of RNA

11 of 934

1.41

2.72

1.40e-13

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0030684

Preribosome

6 of 45

2.46

5.16

4.82e-11

GOCC:0031428

Box C/D snoRNP complex

3 of 6

3.04

3.09

2.32e-06

GOCC:1990904

Ribonucleoprotein complex

8 of 441

1.6

2.83

1.72e-09

GOCC:0005730

Nucleolus

6 of 215

1.78

2.8

1.31e-07

GOCC:0032040

Small-subunit processome

2 of 8

2.74

1.6

0.0012

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0853

WD repeat

5 of 281

1.59

1.8

3.67e-05

KW-0698

rRNA processing

2 of 23

2.28

1.07

0.0103

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF08156

NOP5NT (NUC127) domain

2 of 2

3.34

1.43

0.0027

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00931

NOSIC (NUC001) domain

2 of 3

3.16

1.73

0.00077

SM00320

WD40 repeats

5 of 291

1.57

1.66

9.63e-05

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