SET12654.1 protein (Anaerobranca gottschalkii)

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second shell of interactors

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Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

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co-expression

protein homology

Your Input:

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Score

SET12654.1

NAD(P)-dependent iron-only hydrogenase catalytic subunit. (581 aa)

Predicted Functional Partners:

SES65499.1

0.999

SET12671.1

0.999

SET12705.1

0.999

SES65399.1

0.997

SES65534.1

0.997

SET12690.1

0.997

SES65445.1

0.996

SES62842.1

0.993

SES82812.1

0.993

SES65482.1

0.991

Your Current Organism:

Anaerobranca gottschalkii

NCBI taxonomy Id: 1120990
Other names: A. gottschalkii DSM 13577, Anaerobranca gottschalkii DSM 13577

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SES62842.1	SES65399.1	SAMN03080614_100192	SAMN03080614_100230	Sulfide dehydrogenase (flavoprotein) subunit SudA.	Iron only hydrogenase large subunit, C-terminal domain.	0.910
SES62842.1	SES65445.1	SAMN03080614_100192	SAMN03080614_100233	Sulfide dehydrogenase (flavoprotein) subunit SudA.	NADH-quinone oxidoreductase subunit E.	0.507
SES62842.1	SES65499.1	SAMN03080614_100192	SAMN03080614_100236	Sulfide dehydrogenase (flavoprotein) subunit SudA.	NAD(P)-dependent iron-only hydrogenase diaphorase component flavoprotein.	0.996
SES62842.1	SES65534.1	SAMN03080614_100192	SAMN03080614_100238	Sulfide dehydrogenase (flavoprotein) subunit SudA.	Formate dehydrogenase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	0.939
SES62842.1	SES82812.1	SAMN03080614_100192	SAMN03080614_10113	Sulfide dehydrogenase (flavoprotein) subunit SudA.	Uncharacterized conserved protein, DUF362 family.	0.655
SES62842.1	SET12654.1	SAMN03080614_100192	SAMN03080614_105312	Sulfide dehydrogenase (flavoprotein) subunit SudA.	NAD(P)-dependent iron-only hydrogenase catalytic subunit.	0.993
SES62842.1	SET12671.1	SAMN03080614_100192	SAMN03080614_105313	Sulfide dehydrogenase (flavoprotein) subunit SudA.	NAD(P)-dependent iron-only hydrogenase diaphorase component flavoprotein.	0.993
SES62842.1	SET12705.1	SAMN03080614_100192	SAMN03080614_105315	Sulfide dehydrogenase (flavoprotein) subunit SudA.	NADH-quinone oxidoreductase subunit E.	0.507
SES65399.1	SES62842.1	SAMN03080614_100230	SAMN03080614_100192	Iron only hydrogenase large subunit, C-terminal domain.	Sulfide dehydrogenase (flavoprotein) subunit SudA.	0.910
SES65399.1	SES65445.1	SAMN03080614_100230	SAMN03080614_100233	Iron only hydrogenase large subunit, C-terminal domain.	NADH-quinone oxidoreductase subunit E.	0.987
SES65399.1	SES65482.1	SAMN03080614_100230	SAMN03080614_100235	Iron only hydrogenase large subunit, C-terminal domain.	NAD(P)-dependent iron-only hydrogenase iron-sulfur protein.	0.990
SES65399.1	SES65499.1	SAMN03080614_100230	SAMN03080614_100236	Iron only hydrogenase large subunit, C-terminal domain.	NAD(P)-dependent iron-only hydrogenase diaphorase component flavoprotein.	0.999
SES65399.1	SES65534.1	SAMN03080614_100230	SAMN03080614_100238	Iron only hydrogenase large subunit, C-terminal domain.	Formate dehydrogenase, alpha subunit; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.	0.991
SES65399.1	SES82812.1	SAMN03080614_100230	SAMN03080614_10113	Iron only hydrogenase large subunit, C-terminal domain.	Uncharacterized conserved protein, DUF362 family.	0.991
SES65399.1	SET12654.1	SAMN03080614_100230	SAMN03080614_105312	Iron only hydrogenase large subunit, C-terminal domain.	NAD(P)-dependent iron-only hydrogenase catalytic subunit.	0.997
SES65399.1	SET12671.1	SAMN03080614_100230	SAMN03080614_105313	Iron only hydrogenase large subunit, C-terminal domain.	NAD(P)-dependent iron-only hydrogenase diaphorase component flavoprotein.	0.997
SES65399.1	SET12690.1	SAMN03080614_100230	SAMN03080614_105314	Iron only hydrogenase large subunit, C-terminal domain.	NADP-reducing hydrogenase subunit HndB.	0.971
SES65399.1	SET12705.1	SAMN03080614_100230	SAMN03080614_105315	Iron only hydrogenase large subunit, C-terminal domain.	NADH-quinone oxidoreductase subunit E.	0.962
SES65445.1	SES62842.1	SAMN03080614_100233	SAMN03080614_100192	NADH-quinone oxidoreductase subunit E.	Sulfide dehydrogenase (flavoprotein) subunit SudA.	0.507
SES65445.1	SES65399.1	SAMN03080614_100233	SAMN03080614_100230	NADH-quinone oxidoreductase subunit E.	Iron only hydrogenase large subunit, C-terminal domain.	0.987

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

53

average node degree:

9.64

avg. local clustering coefficient:

0.962

expected number of edges:

11

PPI enrichment p-value:

< 1.0e-16

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1902600

Proton transmembrane transport

4 of 26

1.73

1.4

0.0011

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004129

Cytochrome-c oxidase activity

3 of 5

2.32

1.9

0.00025

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

4 of 22

1.8

1.73

0.00020

GO:0015078

Proton transmembrane transporter activity

4 of 28

1.7

1.63

0.00025

GO:0009055

Electron transfer activity

5 of 49

1.55

1.58

0.00015

GO:0022853

Active ion transmembrane transporter activity

4 of 32

1.64

1.58

0.00026

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016021

Integral component of membrane

11 of 819

0.67

0.63

6.13e-06

GO:0005886

Plasma membrane

8 of 616

0.66

0.52

0.0017

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2400

Oxidative phosphorylation, and SLBB domain

10 of 42

1.92

5.35

3.99e-16

CL:2453

Mixed, incl. Respiratory chain, and Peptidase M16 inactive domain

6 of 12

2.24

4.46

4.02e-10

CL:2396

Mixed, incl. Oxidative phosphorylation, and Heme binding

11 of 77

1.7

4.27

3.99e-16

CL:2457

Respiratory chain, and Rieske [2Fe-2S] domain

5 of 7

2.4

4.06

8.85e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00190

Oxidative phosphorylation

9 of 64

1.69

3.71

1.21e-12

map01100

Metabolic pathways

10 of 1522

0.36

0.26

0.0406

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

3 of 30

1.54

0.89

0.0134

GOCC:0031975

Envelope

4 of 116

1.08

0.62

0.0247

GOCC:0016020

Membrane

9 of 721

0.64

0.48

0.0034

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0249

Electron transport

3 of 12

1.94

1.51

0.00096

KW-0186

Copper

2 of 2

2.54

1.48

0.0019

KW-0350

Heme biosynthesis

2 of 3

2.37

1.39

0.0026

KW-0679

Respiratory chain

2 of 6

2.07

1.16

0.0062

KW-1133

Transmembrane helix

9 of 648

0.69

0.55

0.00096

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