SHH24054.1 protein (Asaccharospora irregularis)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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co-expression

protein homology

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Score

SHH24054.1

Type IV pilus assembly protein PilB. (431 aa)

Predicted Functional Partners:

SHH24085.1

0.989

SHH13542.1

0.963

SHH13512.1

0.953

SHH33840.1

0.873

SHH24111.1

0.790

SHH24024.1

0.773

SHH13422.1

0.755

SHH00635.1

0.694

SHH13450.1

0.689

SHH25475.1

0.689

Your Current Organism:

Asaccharospora irregularis

NCBI taxonomy Id: 1121321
Other names: A. irregularis DSM 2635, Asaccharospora irregularis DSM 2635, Clostridium irregulare DSM 2635

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SHH00635.1	SHH13512.1	SAMN04488530_11420	SAMN04488530_12136	Competence protein ComGC.	Type II secretion system (T2SS), protein F.	0.575
SHH00635.1	SHH13542.1	SAMN04488530_11420	SAMN04488530_12137	Competence protein ComGC.	Type IV pilus assembly protein PilM.	0.513
SHH00635.1	SHH24054.1	SAMN04488530_11420	SAMN04488530_1298	Competence protein ComGC.	Type IV pilus assembly protein PilB.	0.694
SHH00635.1	SHH24085.1	SAMN04488530_11420	SAMN04488530_1299	Competence protein ComGC.	Type IV pilus assembly protein PilC.	0.575
SHH00635.1	SHH24111.1	SAMN04488530_11420	SAMN04488530_12910	Competence protein ComGC.	Type IV pilus assembly protein PilA.	0.482
SHH00635.1	SHH33840.1	SAMN04488530_11420	SAMN04488530_13717	Competence protein ComGC.	Leader peptidase (prepilin peptidase) / N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	0.481
SHH13422.1	SHH13512.1	SAMN04488530_12133	SAMN04488530_12136	Prepilin-type N-terminal cleavage/methylation domain-containing protein.	Type II secretion system (T2SS), protein F.	0.810
SHH13422.1	SHH13542.1	SAMN04488530_12133	SAMN04488530_12137	Prepilin-type N-terminal cleavage/methylation domain-containing protein.	Type IV pilus assembly protein PilM.	0.642
SHH13422.1	SHH24054.1	SAMN04488530_12133	SAMN04488530_1298	Prepilin-type N-terminal cleavage/methylation domain-containing protein.	Type IV pilus assembly protein PilB.	0.755
SHH13422.1	SHH24085.1	SAMN04488530_12133	SAMN04488530_1299	Prepilin-type N-terminal cleavage/methylation domain-containing protein.	Type IV pilus assembly protein PilC.	0.707
SHH13422.1	SHH24111.1	SAMN04488530_12133	SAMN04488530_12910	Prepilin-type N-terminal cleavage/methylation domain-containing protein.	Type IV pilus assembly protein PilA.	0.679
SHH13422.1	SHH33840.1	SAMN04488530_12133	SAMN04488530_13717	Prepilin-type N-terminal cleavage/methylation domain-containing protein.	Leader peptidase (prepilin peptidase) / N-methyltransferase; Cleaves type-4 fimbrial leader sequence and methylates the N- terminal (generally Phe) residue.	0.661
SHH13450.1	SHH13512.1	SAMN04488530_12134	SAMN04488530_12136	Hypothetical protein.	Type II secretion system (T2SS), protein F.	0.741
SHH13450.1	SHH13542.1	SAMN04488530_12134	SAMN04488530_12137	Hypothetical protein.	Type IV pilus assembly protein PilM.	0.701
SHH13450.1	SHH24054.1	SAMN04488530_12134	SAMN04488530_1298	Hypothetical protein.	Type IV pilus assembly protein PilB.	0.689
SHH13450.1	SHH24085.1	SAMN04488530_12134	SAMN04488530_1299	Hypothetical protein.	Type IV pilus assembly protein PilC.	0.570
SHH13512.1	SHH00635.1	SAMN04488530_12136	SAMN04488530_11420	Type II secretion system (T2SS), protein F.	Competence protein ComGC.	0.575
SHH13512.1	SHH13422.1	SAMN04488530_12136	SAMN04488530_12133	Type II secretion system (T2SS), protein F.	Prepilin-type N-terminal cleavage/methylation domain-containing protein.	0.810
SHH13512.1	SHH13450.1	SAMN04488530_12136	SAMN04488530_12134	Type II secretion system (T2SS), protein F.	Hypothetical protein.	0.741
SHH13512.1	SHH13542.1	SAMN04488530_12136	SAMN04488530_12137	Type II secretion system (T2SS), protein F.	Type IV pilus assembly protein PilM.	0.989

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Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.809

expected number of edges:

26

PPI enrichment p-value:

0.0076

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0051536

Iron-sulfur cluster binding

5 of 51

1.39

1.31

0.00036

GO:0016491

Oxidoreductase activity

9 of 195

1.06

1.22

1.63e-06

GO:0051538

3 iron, 4 sulfur cluster binding

2 of 4

2.1

0.92

0.0188

GO:0050660

Flavin adenine dinucleotide binding

3 of 25

1.48

0.81

0.0188

GO:0071949

FAD binding

2 of 9

1.74

0.69

0.0460

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:597

Mixed, incl. Oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor, and Oxidoreductase NAD-binding domain

5 of 16

1.89

2.67

1.04e-06

CL:563

Mixed, incl. Fatty acid metabolic process, and Oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor

6 of 33

1.66

2.37

7.11e-07

CL:471

Mixed, incl. Oxidative phosphorylation, and Fatty acid metabolic process

8 of 79

1.4

2.07

6.59e-08

CL:617

Mixed, incl. FAD linked oxidases, C-terminal domain, and Isoprene biosynthesis

3 of 6

2.1

1.75

0.00039

CL:600

Oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor, and Oxidoreductase NAD-binding domain

2 of 5

2.0

0.84

0.0256

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map01120

Microbial metabolism in diverse environments

6 of 163

0.96

0.77

0.0018

map01100

Metabolic pathways

9 of 800

0.45

0.31

0.0245

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070469

Respirasome

3 of 23

1.51

0.75

0.0277

GOCC:1990204

Oxidoreductase complex

3 of 32

1.37

0.68

0.0342

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0560

Oxidoreductase

5 of 94

1.12

0.83

0.0046

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02913

FAD linked oxidases, C-terminal domain

2 of 2

2.4

0.8

0.0347

PF13534

4Fe-4S dicluster domain

2 of 3

2.22

0.79

0.0347

PF01565

FAD binding domain

2 of 3

2.22

0.79

0.0347

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