KDR95852.1 protein (Peptoclostridium litorale)

Nodes:

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

KDR95852.1

Diguanylate cyclase. (459 aa)

Predicted Functional Partners:

KDR95606.1

0.999

KDR95527.1

0.998

aruS

0.998

barA

0.998

KDR96787.1

0.996

KDR96017.1

0.996

KDR94562.1

0.995

cheV

0.994

KDR94559.1

0.993

cph1

0.991

Your Current Organism:

Peptoclostridium litorale

NCBI taxonomy Id: 1121324
Other names: Clostridium litorale (strain W6), Clostridium litorale DSM 5388, P. litorale DSM 5388, Peptoclostridium litorale DSM 5388, bacterium W6

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KDR94559.1	KDR94562.1	CLIT_14c00200	CLIT_14c00230	ATP-binding protein.	Hypothetical protein.	0.998
KDR94559.1	KDR95527.1	CLIT_14c00200	CLIT_10c02540	ATP-binding protein.	Diguanylate cyclase/phosphodiesterase.	0.997
KDR94559.1	KDR95606.1	CLIT_14c00200	CLIT_10c03330	ATP-binding protein.	Response regulator receiver protein.	0.999
KDR94559.1	KDR95852.1	CLIT_14c00200	CLIT_8c00210	ATP-binding protein.	Diguanylate cyclase.	0.993
KDR94559.1	KDR96017.1	CLIT_14c00200	CLIT_5c00270	ATP-binding protein.	Diguanylate cyclase/phosphodiesterase.	0.979
KDR94559.1	KDR96787.1	CLIT_14c00200	CLIT_2c03930	ATP-binding protein.	Sensor histidine kinase response regulator.	0.999
KDR94559.1	aruS	CLIT_14c00200	CLIT_10c03350	ATP-binding protein.	Sensor histidine kinase AruS.	0.999
KDR94559.1	barA	CLIT_14c00200	CLIT_2c02550	ATP-binding protein.	Signal transduction histidine-protein kinase BarA.	0.999
KDR94559.1	cheV	CLIT_14c00200	CLIT_14c00090	ATP-binding protein.	Chemotaxis protein CheV.	0.990
KDR94559.1	cph1	CLIT_14c00200	CLIT_2c00100	ATP-binding protein.	Phytochrome-like protein Cph2.	0.972
KDR94562.1	KDR94559.1	CLIT_14c00230	CLIT_14c00200	Hypothetical protein.	ATP-binding protein.	0.998
KDR94562.1	KDR95527.1	CLIT_14c00230	CLIT_10c02540	Hypothetical protein.	Diguanylate cyclase/phosphodiesterase.	0.996
KDR94562.1	KDR95606.1	CLIT_14c00230	CLIT_10c03330	Hypothetical protein.	Response regulator receiver protein.	0.997
KDR94562.1	KDR95852.1	CLIT_14c00230	CLIT_8c00210	Hypothetical protein.	Diguanylate cyclase.	0.995
KDR94562.1	KDR96017.1	CLIT_14c00230	CLIT_5c00270	Hypothetical protein.	Diguanylate cyclase/phosphodiesterase.	0.996
KDR94562.1	KDR96787.1	CLIT_14c00230	CLIT_2c03930	Hypothetical protein.	Sensor histidine kinase response regulator.	0.996
KDR94562.1	aruS	CLIT_14c00230	CLIT_10c03350	Hypothetical protein.	Sensor histidine kinase AruS.	0.998
KDR94562.1	barA	CLIT_14c00230	CLIT_2c02550	Hypothetical protein.	Signal transduction histidine-protein kinase BarA.	0.997
KDR94562.1	cheV	CLIT_14c00230	CLIT_14c00090	Hypothetical protein.	Chemotaxis protein CheV.	0.991
KDR94562.1	cph1	CLIT_14c00230	CLIT_2c00100	Hypothetical protein.	Phytochrome-like protein Cph2.	0.995

page 1 of 6

Network Stats

number of nodes:

11

number of edges:

39

average node degree:

7.09

avg. local clustering coefficient:

0.968

expected number of edges:

11

PPI enrichment p-value:

3.84e-11

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006525

Arginine metabolic process

11 of 34

2.23

8.23

2.82e-21

GO:0006526

Arginine biosynthetic process

9 of 17

2.45

8.04

4.90e-18

GO:0006591

Ornithine metabolic process

4 of 6

2.55

3.56

1.65e-07

GO:0042450

Arginine biosynthetic process via ornithine

2 of 2

2.72

1.57

0.0014

GO:0044205

De novo UMP biosynthetic process

2 of 7

2.18

1.12

0.0079

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0103045

Methione N-acyltransferase activity

2 of 2

2.72

0.93

0.0203

GO:0004088

Carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity

2 of 2

2.72

0.93

0.0203

GO:0004042

acetyl-CoA:L-glutamate N-acetyltransferase activity

2 of 2

2.72

0.93

0.0203

GO:0016774

Phosphotransferase activity, carboxyl group as acceptor

2 of 7

2.18

0.82

0.0303

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

3 of 51

1.49

0.73

0.0303

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 1829

0.5

0.42

0.00052

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1505

Arginine biosynthesis, and Amino acid antiporter

9 of 15

2.5

8.22

4.37e-18

CL:1510

Arginine biosynthesis

6 of 6

2.72

6.12

1.70e-12

CL:1367

Cellular amino acid biosynthetic process, and Ribonucleoside monophosphate biosynthetic process

11 of 152

1.58

3.6

3.78e-15

CL:1525

Amino acid antiporter, and Arginine catabolic process to ornithine

2 of 5

2.33

1.03

0.0127

CL:1578

Pyrimidine biosynthesis, and Dihydroorotase, conserved site

2 of 6

2.25

0.99

0.0148

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pfn00220

Arginine biosynthesis

9 of 36

2.12

6.25

3.12e-16

pfn00250

Alanine, aspartate and glutamate metabolism

4 of 39

1.74

1.95

3.78e-05

pfn01230

Biosynthesis of amino acids

7 of 179

1.32

1.75

6.17e-07

pfn01210

2-Oxocarboxylic acid metabolism

4 of 51

1.62

1.75

6.84e-05

pfn01110

Biosynthesis of secondary metabolites

8 of 614

0.84

0.78

6.84e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005951

Carbamoyl-phosphate synthase complex

2 of 2

2.72

1.18

0.0073

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0055

Arginine biosynthesis

9 of 13

2.56

8.87

2.96e-19

KW-0963

Cytoplasm

8 of 311

1.13

1.38

8.14e-07

KW-0665

Pyrimidine biosynthesis

2 of 10

2.03

1.0

0.0124

KW-0436

Ligase

3 of 73

1.34

0.8

0.0152

KW-0808

Transferase

5 of 407

0.81

0.51

0.0216

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00696

Amino acid kinase family

3 of 6

2.42

1.85

0.00035

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036393

Acetylglutamate kinase-like superfamily

3 of 6

2.42

1.71

0.00065

IPR001048

Aspartate/glutamate/uridylate kinase

3 of 6

2.42

1.71

0.00065

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