node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHJ91235.1 | SHK10566.1 | SAMN02745248_01288 | SAMN02745248_01774 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.822 |
SHJ91235.1 | fhs | SAMN02745248_01288 | SAMN02745248_00946 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.593 |
SHJ91235.1 | glyA | SAMN02745248_01288 | SAMN02745248_01908 | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.615 |
SHK00933.1 | SHK10566.1 | SAMN02745248_01563 | SAMN02745248_01774 | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.809 |
SHK00933.1 | SHK21579.1 | SAMN02745248_01563 | SAMN02745248_02065 | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.875 |
SHK00933.1 | fhs | SAMN02745248_01563 | SAMN02745248_00946 | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.983 |
SHK00933.1 | fmt | SAMN02745248_01563 | SAMN02745248_00111 | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.600 |
SHK00933.1 | gcvT | SAMN02745248_01563 | SAMN02745248_02608 | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.919 |
SHK00933.1 | glyA | SAMN02745248_01563 | SAMN02745248_01908 | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.992 |
SHK00933.1 | purN | SAMN02745248_01563 | SAMN02745248_01602 | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.999 |
SHK10566.1 | SHJ91235.1 | SAMN02745248_01774 | SAMN02745248_01288 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.822 |
SHK10566.1 | SHK00933.1 | SAMN02745248_01774 | SAMN02745248_01563 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase. | 0.809 |
SHK10566.1 | SHK10591.1 | SAMN02745248_01774 | SAMN02745248_01775 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | PAS domain S-box-containing protein/diguanylate cyclase (GGDEF) domain-containing protein. | 0.788 |
SHK10566.1 | SHK21579.1 | SAMN02745248_01774 | SAMN02745248_02065 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase (FAD); Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.815 |
SHK10566.1 | SHK43758.1 | SAMN02745248_01774 | SAMN02745248_02538 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Dihydrofolate synthase / folylpolyglutamate synthase; Belongs to the folylpolyglutamate synthase family. | 0.822 |
SHK10566.1 | fhs | SAMN02745248_01774 | SAMN02745248_00946 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.818 |
SHK10566.1 | fmt | SAMN02745248_01774 | SAMN02745248_00111 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.817 |
SHK10566.1 | gcvT | SAMN02745248_01774 | SAMN02745248_02608 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.809 |
SHK10566.1 | glyA | SAMN02745248_01774 | SAMN02745248_01908 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.840 |
SHK10566.1 | purN | SAMN02745248_01774 | SAMN02745248_01602 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Formyltetrahydrofolate-dependent phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.810 |