STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
spoIVaStage IV sporulation protein A. (507 aa)    
Predicted Functional Partners:
spoIIIAA
Stage III sporulation protein AA.
  
  
 0.906
spoIIID
Stage III sporulation protein D.
  
  
 0.902
spoIIIAD1
Stage III sporulation protein AD.
  
    0.866
spoIIR
Stage II sporulation protein R.
  
   
 0.859
spoIIIAF
Stage III sporulation protein AG.
  
  
 0.855
spoIIAB
Anti-sigma F factor SpoIIAB; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
  
 0.847
gpr
Germination protease Gpr; Initiates the rapid degradation of small, acid-soluble proteins during spore germination; Belongs to the peptidase A25 family.
  
   
 0.840
spoIID
Stage II sporulation protein D.
  
  
 0.836
spoIIE
Stage II sporulation protein E.
  
   
 0.835
spo0A1
Stage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
  
   
 0.834
Your Current Organism:
Thermoclostridium stercorarium
NCBI taxonomy Id: 1121335
Other names: Clostridium stercorarium subsp. stercorarium DSM 8532, T. stercorarium subsp. stercorarium DSM 8532, Thermoclostridium stercorarium subsp. stercorarium DSM 8532
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