STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nadAQuinolinate synthase A; Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate. (305 aa)    
Predicted Functional Partners:
nadC
Nicotinate-nucleotide pyrophosphorylase; Carboxylating; Belongs to the NadC/ModD family.
 
 0.999
nadB1
L-aspartate oxidase 1; Catalyzes the oxidation of L-aspartate to iminoaspartate.
 0.999
cysE
Serine acetyltransferase CysE.
  
    0.886
nadE
Glutamine-dependent NAD(+) synthetase NadE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
  
  
 0.753
gmk
Guanylate kinase Gmk; Essential for recycling GMP and indirectly, cGMP.
  
  
 0.726
valS
valine--tRNA ligase ValS; Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA- dependent manner; Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.
      0.697
dapA
Dihydrodipicolinate synthase DapA; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
  
 0.640
cinA
Putative competence-damage inducible protein CinA; Belongs to the CinA family.
     
 0.611
birA
Bifunctional protein biotin operon repressor/biotin--[acetyl-CoA-carboxylase] synthetase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family.
     
 0.608
infB
Translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
  
  
 0.583
Your Current Organism:
Thermoclostridium stercorarium
NCBI taxonomy Id: 1121335
Other names: Clostridium stercorarium subsp. stercorarium DSM 8532, T. stercorarium subsp. stercorarium DSM 8532, Thermoclostridium stercorarium subsp. stercorarium DSM 8532
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