kamA2 protein (Thermoclostridium stercorarium)

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second shell of interactors

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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Score

kamA2

L-lysine 2,3-aminomutase KamA. (370 aa)

Predicted Functional Partners:

speA1

0.900

AGC68777.1

0.900

ddl1

0.895

lysA

0.802

cheR1

0.572

cheR2

0.572

cheR3

0.572

nifJ1

0.565

nifJ2

0.485

Your Current Organism:

Thermoclostridium stercorarium

NCBI taxonomy Id: 1121335
Other names: Clostridium stercorarium subsp. stercorarium DSM 8532, T. stercorarium subsp. stercorarium DSM 8532, Thermoclostridium stercorarium subsp. stercorarium DSM 8532

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGC68777.1	kamA2	Cst_c17970	Cst_c16010	Saccharopine dehydrogenase.	L-lysine 2,3-aminomutase KamA.	0.900
AGC68777.1	lysA	Cst_c17970	Cst_c20050	Saccharopine dehydrogenase.	Diaminopimelate decarboxylase LysA; Specifically catalyzes the decarboxylation of meso- diaminopimelate (meso-DAP) to L-lysine.	0.918
AGC68777.1	speA1	Cst_c17970	Cst_c12350	Saccharopine dehydrogenase.	Arginine decarboxylase SpeA.	0.911
cheR1	cheR2	Cst_c15080	Cst_c17710	Chemotaxis protein methyltransferase CheR.	Chemotaxis protein methyltransferase CheR.	0.919
cheR1	cheR3	Cst_c15080	Cst_c17880	Chemotaxis protein methyltransferase CheR.	Chemotaxis protein methyltransferase 2.	0.919
cheR1	kamA2	Cst_c15080	Cst_c16010	Chemotaxis protein methyltransferase CheR.	L-lysine 2,3-aminomutase KamA.	0.572
cheR1	nifJ1	Cst_c15080	Cst_c06770	Chemotaxis protein methyltransferase CheR.	Pyruvate-flavodoxin oxidoreductase NifJ.	0.865
cheR1	nifJ2	Cst_c15080	Cst_c14530	Chemotaxis protein methyltransferase CheR.	Pyruvate-flavodoxin oxidoreductase NifJ.	0.882
cheR2	cheR1	Cst_c17710	Cst_c15080	Chemotaxis protein methyltransferase CheR.	Chemotaxis protein methyltransferase CheR.	0.919
cheR2	cheR3	Cst_c17710	Cst_c17880	Chemotaxis protein methyltransferase CheR.	Chemotaxis protein methyltransferase 2.	0.918
cheR2	kamA2	Cst_c17710	Cst_c16010	Chemotaxis protein methyltransferase CheR.	L-lysine 2,3-aminomutase KamA.	0.572
cheR2	nifJ1	Cst_c17710	Cst_c06770	Chemotaxis protein methyltransferase CheR.	Pyruvate-flavodoxin oxidoreductase NifJ.	0.865
cheR2	nifJ2	Cst_c17710	Cst_c14530	Chemotaxis protein methyltransferase CheR.	Pyruvate-flavodoxin oxidoreductase NifJ.	0.882
cheR3	cheR1	Cst_c17880	Cst_c15080	Chemotaxis protein methyltransferase 2.	Chemotaxis protein methyltransferase CheR.	0.919
cheR3	cheR2	Cst_c17880	Cst_c17710	Chemotaxis protein methyltransferase 2.	Chemotaxis protein methyltransferase CheR.	0.918
cheR3	kamA2	Cst_c17880	Cst_c16010	Chemotaxis protein methyltransferase 2.	L-lysine 2,3-aminomutase KamA.	0.572
cheR3	nifJ1	Cst_c17880	Cst_c06770	Chemotaxis protein methyltransferase 2.	Pyruvate-flavodoxin oxidoreductase NifJ.	0.865
cheR3	nifJ2	Cst_c17880	Cst_c14530	Chemotaxis protein methyltransferase 2.	Pyruvate-flavodoxin oxidoreductase NifJ.	0.882
ddl1	kamA2	Cst_c16020	Cst_c16010	D-alanine--D-alanine ligase Ddl; Cell wall formation; Belongs to the D-alanine--D-alanine ligase family.	L-lysine 2,3-aminomutase KamA.	0.895
kamA2	AGC68777.1	Cst_c16010	Cst_c17970	L-lysine 2,3-aminomutase KamA.	Saccharopine dehydrogenase.	0.900

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.954

expected number of edges:

40

PPI enrichment p-value:

0.921

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0016310

Phosphorylation

7 of 160

1.22

1.28

6.14e-05

GO:0007165

Signal transduction

7 of 188

1.15

1.16

9.03e-05

GO:0050794

Regulation of cellular process

8 of 502

0.78

0.63

0.0012

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004672

Protein kinase activity

7 of 92

1.46

2.0

8.47e-07

GO:0000155

Phosphorelay sensor kinase activity

6 of 68

1.52

1.98

3.63e-06

GO:0008556

P-type potassium transmembrane transporter activity

2 of 3

2.4

1.27

0.0046

GO:0016772

Transferase activity, transferring phosphorus-containing groups

8 of 245

1.09

1.24

3.63e-06

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005886

Plasma membrane

7 of 563

0.67

0.47

0.0087

GO:0016021

Integral component of membrane

9 of 913

0.57

0.42

0.0066

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3493

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and EAL domain

6 of 21

2.03

3.56

1.22e-08

CL:3496

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain, and cheY-homologous receiver domain

5 of 13

2.16

3.49

5.10e-08

CL:3481

Phosphorelay sensor kinase activity, and Domain present in phytochromes and cGMP-specific phosphodiesterases.

7 of 47

1.75

3.02

1.22e-08

CL:3939

P-type ion transporter activity, and UspA

2 of 5

2.18

1.06

0.0103

CL:3500

Mixed, incl. PAC motif, and Sodium/solute symporter

2 of 6

2.1

1.01

0.0126

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0031004

Potassium ion-transporting ATPase complex

2 of 3

2.4

0.93

0.0194

GOCC:0016020

Membrane

8 of 786

0.58

0.39

0.0194

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0597

Phosphoprotein

6 of 95

1.38

1.61

1.75e-05

KW-0633

Potassium transport

2 of 4

2.28

1.05

0.0113

KW-0418

Kinase

4 of 108

1.15

0.75

0.0113

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003661

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain

6 of 42

1.73

2.51

6.46e-07

IPR036097

Signal transduction histidine kinase, dimerisation/phosphoacceptor domain superfamily

6 of 47

1.68

2.41

8.02e-07

IPR036890

Histidine kinase/HSP90-like ATPase superfamily

7 of 67

1.6

2.39

2.25e-07

IPR005467

Histidine kinase domain

6 of 50

1.66

2.35

8.48e-07

IPR013656

PAS fold-4

4 of 15

2.0

2.18

3.39e-05

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00388

His Kinase A (phosphoacceptor) domain

6 of 45

1.7

2.63

1.61e-07

SM00387

Histidine kinase-like ATPases

6 of 60

1.58

2.3

4.01e-07

SM00091

PAS domain

4 of 30

1.7

1.85

5.75e-05

SM00086

Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain)

3 of 16

1.85

1.65

0.00038

SM00448

cheY-homologous receiver domain

5 of 81

1.37

1.48

5.75e-05

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