node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AGC68136.1 | metH | Cst_c11400 | Cst_c26970 | Hypothetical protein. | Methionine synthase MetH. | 0.900 |
AGC68136.1 | metK1 | Cst_c11400 | Cst_c23370 | Hypothetical protein. | S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.900 |
AGC68136.1 | metK2 | Cst_c11400 | Cst_c25930 | Hypothetical protein. | S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.900 |
AGC69298.1 | metK1 | Cst_c23380 | Cst_c23370 | Radical SAM domain protein. | S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.754 |
ahcY | glyA | Cst_c21990 | Cst_c07730 | Adenosylhomocysteinase AhcY; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Pyridoxal-phosphate-dependent serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.572 |
ahcY | guaA | Cst_c21990 | Cst_c14460 | Adenosylhomocysteinase AhcY; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.436 |
ahcY | metH | Cst_c21990 | Cst_c26970 | Adenosylhomocysteinase AhcY; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | Methionine synthase MetH. | 0.972 |
ahcY | metK1 | Cst_c21990 | Cst_c23370 | Adenosylhomocysteinase AhcY; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.730 |
ahcY | metK2 | Cst_c21990 | Cst_c25930 | Adenosylhomocysteinase AhcY; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.733 |
birA | guaA | Cst_c26740 | Cst_c14460 | Bifunctional protein biotin operon repressor/biotin--[acetyl-CoA-carboxylase] synthetase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.780 |
birA | metK1 | Cst_c26740 | Cst_c23370 | Bifunctional protein biotin operon repressor/biotin--[acetyl-CoA-carboxylase] synthetase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.644 |
birA | metK2 | Cst_c26740 | Cst_c25930 | Bifunctional protein biotin operon repressor/biotin--[acetyl-CoA-carboxylase] synthetase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.644 |
glyA | ahcY | Cst_c07730 | Cst_c21990 | Pyridoxal-phosphate-dependent serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Adenosylhomocysteinase AhcY; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.572 |
glyA | guaA | Cst_c07730 | Cst_c14460 | Pyridoxal-phosphate-dependent serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.789 |
glyA | metH | Cst_c07730 | Cst_c26970 | Pyridoxal-phosphate-dependent serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Methionine synthase MetH. | 0.957 |
glyA | metK1 | Cst_c07730 | Cst_c23370 | Pyridoxal-phosphate-dependent serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.664 |
glyA | metK2 | Cst_c07730 | Cst_c25930 | Pyridoxal-phosphate-dependent serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | S-adenosylmethionine synthase MetK; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.664 |
guaA | ahcY | Cst_c14460 | Cst_c21990 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Adenosylhomocysteinase AhcY; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.436 |
guaA | birA | Cst_c14460 | Cst_c26740 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Bifunctional protein biotin operon repressor/biotin--[acetyl-CoA-carboxylase] synthetase BirA; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor; Belongs to the biotin--protein ligase family. | 0.780 |
guaA | glyA | Cst_c14460 | Cst_c07730 | GMP synthase; Catalyzes the synthesis of GMP from XMP. | Pyridoxal-phosphate-dependent serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.789 |