SHO42902.1 protein (Desulfopila aestuarii) - STRING interaction network

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

SHO42902.1

Enoyl-[acyl-carrier-protein] reductase [NADH]. (270 aa)

Predicted Functional Partners:

SHO47269.1

0.994

SHO45872.1

0.993

SHO51843.1

0.993

SHO45552.1

0.986

SHO51021.1

0.985

acpP

0.981

SHO45884.1

0.972

SHO49870.1

0.972

SHO46335.1

0.966

SHO45875.1

0.955

Your Current Organism:

Desulfopila aestuarii

NCBI taxonomy Id: 1121416
Other names: D. aestuarii DSM 18488, Desulfopila aestuarii DSM 18488

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SHO42902.1	SHO45552.1	SAMN02745220_00206	SAMN02745220_01129	Enoyl-[acyl-carrier-protein] reductase [NADH].	[acyl-carrier-protein] S-malonyltransferase.	0.986
SHO42902.1	SHO45872.1	SAMN02745220_00206	SAMN02745220_01244	Enoyl-[acyl-carrier-protein] reductase [NADH].	3-oxoacyl-[acyl-carrier-protein] synthase II; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.993
SHO42902.1	SHO45875.1	SAMN02745220_00206	SAMN02745220_01245	Enoyl-[acyl-carrier-protein] reductase [NADH].	Acyl carrier protein.	0.955
SHO42902.1	SHO45884.1	SAMN02745220_00206	SAMN02745220_01249	Enoyl-[acyl-carrier-protein] reductase [NADH].	3-hydroxyacyl-[acyl-carrier-protein] dehydratase.	0.972
SHO42902.1	SHO46335.1	SAMN02745220_00206	SAMN02745220_01432	Enoyl-[acyl-carrier-protein] reductase [NADH].	1-acyl-sn-glycerol-3-phosphate acyltransferases.	0.966
SHO42902.1	SHO47269.1	SAMN02745220_00206	SAMN02745220_01805	Enoyl-[acyl-carrier-protein] reductase [NADH].	acetyl-CoA carboxylase carboxyl transferase subunit beta.	0.994
SHO42902.1	SHO49870.1	SAMN02745220_00206	SAMN02745220_03123	Enoyl-[acyl-carrier-protein] reductase [NADH].	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II.	0.972
SHO42902.1	SHO51021.1	SAMN02745220_00206	SAMN02745220_03768	Enoyl-[acyl-carrier-protein] reductase [NADH].	3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.	0.985
SHO42902.1	SHO51843.1	SAMN02745220_00206	SAMN02745220_04247	Enoyl-[acyl-carrier-protein] reductase [NADH].	LPS sulfotransferase NodH.	0.993
SHO42902.1	acpP	SAMN02745220_00206	SAMN02745220_03769	Enoyl-[acyl-carrier-protein] reductase [NADH].	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.981
SHO45552.1	SHO42902.1	SAMN02745220_01129	SAMN02745220_00206	[acyl-carrier-protein] S-malonyltransferase.	Enoyl-[acyl-carrier-protein] reductase [NADH].	0.986
SHO45552.1	SHO45872.1	SAMN02745220_01129	SAMN02745220_01244	[acyl-carrier-protein] S-malonyltransferase.	3-oxoacyl-[acyl-carrier-protein] synthase II; Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.	0.999
SHO45552.1	SHO45875.1	SAMN02745220_01129	SAMN02745220_01245	[acyl-carrier-protein] S-malonyltransferase.	Acyl carrier protein.	0.992
SHO45552.1	SHO45884.1	SAMN02745220_01129	SAMN02745220_01249	[acyl-carrier-protein] S-malonyltransferase.	3-hydroxyacyl-[acyl-carrier-protein] dehydratase.	0.982
SHO45552.1	SHO46335.1	SAMN02745220_01129	SAMN02745220_01432	[acyl-carrier-protein] S-malonyltransferase.	1-acyl-sn-glycerol-3-phosphate acyltransferases.	0.998
SHO45552.1	SHO47269.1	SAMN02745220_01129	SAMN02745220_01805	[acyl-carrier-protein] S-malonyltransferase.	acetyl-CoA carboxylase carboxyl transferase subunit beta.	0.999
SHO45552.1	SHO49870.1	SAMN02745220_01129	SAMN02745220_03123	[acyl-carrier-protein] S-malonyltransferase.	Acyl-CoA synthetase (AMP-forming)/AMP-acid ligase II.	0.997
SHO45552.1	SHO51021.1	SAMN02745220_01129	SAMN02745220_03768	[acyl-carrier-protein] S-malonyltransferase.	3-oxoacyl-[acyl-carrier-protein] synthase II; Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP.	0.999
SHO45552.1	SHO51843.1	SAMN02745220_01129	SAMN02745220_04247	[acyl-carrier-protein] S-malonyltransferase.	LPS sulfotransferase NodH.	0.999
SHO45552.1	acpP	SAMN02745220_01129	SAMN02745220_03769	[acyl-carrier-protein] S-malonyltransferase.	Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis.	0.998

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Network Stats

number of nodes:

11

number of edges:

25

average node degree:

4.55

avg. local clustering coefficient:

0.676

expected number of edges:

16

PPI enrichment p-value:

0.0223

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006366

Transcription by RNA polymerase II

6 of 179

1.86

2.89

1.81e-07

GO:0006351

Transcription, DNA-templated

7 of 313

1.69

2.59

1.81e-07

GO:0006367

Transcription initiation from RNA polymerase II promoter

3 of 33

2.3

1.83

0.00034

GO:0045948

Positive regulation of translational initiation

2 of 19

2.36

1.0

0.0148

GO:0030150

Protein import into mitochondrial matrix

2 of 23

2.28

0.92

0.0199

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003899

DNA-directed 5-3 RNA polymerase activity

4 of 21

2.62

3.24

8.12e-07

GO:0031369

Translation initiation factor binding

2 of 17

2.41

1.0

0.0146

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005665

RNA polymerase II, core complex

5 of 14

2.89

5.66

2.56e-11

GO:0055029

Nuclear DNA-directed RNA polymerase complex

7 of 97

2.2

5.0

9.66e-12

GO:0016591

RNA polymerase II, holoenzyme

6 of 71

2.27

4.73

1.04e-10

GO:0005744

TIM23 mitochondrial import inner membrane translocase complex

2 of 9

2.69

1.65

0.00095

GO:0005654

Nucleoplasm

7 of 2180

0.85

0.7

0.0010

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9495

RNA polymerase II, core complex

5 of 8

3.13

5.64

4.38e-11

CL:9468

RNA Polymerase II Pre-transcription Events, and RNA Polymerase III Transcription Initiation From Type 1 Promoter

7 of 181

1.93

3.78

6.36e-10

CL:9476

RNA Polymerase II Pre-transcription Events, and Transcription elongation factor complex

6 of 126

2.02

3.59

8.63e-09

CL:32588

Mitochondrial protein import, and Protein insertion into mitochondrial inner membrane

3 of 38

2.24

1.82

0.00034

CL:32638

TIM23 mitochondrial import inner membrane translocase complex

2 of 5

2.94

1.54

0.0016

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map03020

RNA polymerase

6 of 54

2.38

5.25

1.69e-11

map04623

Cytosolic DNA-sensing pathway

2 of 68

1.81

0.71

0.0443

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-6803529

FGFR2 alternative splicing

6 of 27

2.69

5.95

3.21e-12

MAP-77075

RNA Pol II CTD phosphorylation and interaction with CE

6 of 32

2.61

5.83

4.00e-12

MAP-72086

mRNA Capping

6 of 33

2.6

5.81

4.00e-12

MAP-113418

Formation of the Early Elongation Complex

6 of 36

2.56

5.77

4.00e-12

MAP-76042

RNA Polymerase II Transcription Initiation And Promoter Clearance

6 of 52

2.4

5.21

2.34e-11

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0000428

DNA-directed RNA polymerase complex

7 of 94

2.21

5.03

9.54e-12

GOCC:0055029

Nuclear DNA-directed RNA polymerase complex

6 of 81

2.21

4.39

4.47e-10

GOCC:0005665

RNA polymerase II, core complex

3 of 8

2.91

2.97

3.65e-06

GOCC:0016591

RNA polymerase II, holoenzyme

4 of 59

2.17

2.71

3.65e-06

GOCC:0005744

TIM23 mitochondrial import inner membrane translocase complex

2 of 9

2.69

1.55

0.0015

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0240

DNA-directed RNA polymerase

6 of 30

2.64

6.1

1.23e-12

KW-0804

Transcription

7 of 517

1.47

2.18

1.26e-07

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00662

RNA polymerases D

2 of 2

3.34

1.69

0.00092

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