STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
SHO48217.1Hydrogenase maturation protein, carbamoyltransferase HypF; Involved in the maturation of [NiFe] hydrogenases. Along with HypE, it catalyzes the synthesis of the CN ligands of the active site iron of [NiFe]-hydrogenases. HypF functions as a carbamoyl transferase using carbamoylphosphate as a substrate and transferring the carboxamido moiety in an ATP-dependent reaction to the thiolate of the C-terminal cysteine of HypE yielding a protein-S-carboxamide. (790 aa)    
Predicted Functional Partners:
SHO48212.1
Hydrogenase maturation protein, carbamoyl dehydratase HypE.
 
 
 0.996
SHO48216.1
Hydrogenase maturation protein HypC.
 
 
 0.979
SHO48213.1
Hydrogenase maturation protein HypD; Belongs to the HypD family.
 
  
 0.978
SHO48205.1
Hydrogenase nickel incorporation protein HypB.
 
   
 0.920
SHO48220.1
Hydrogenase large subunit; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 
 0.913
SHO47392.1
Hydrogenase expression/formation protein HypD.
 
  
 0.884
SHO48218.1
Ni/Fe-hydrogenase 1 B-type cytochrome subunit.
 
   
 0.875
SHO48221.1
Hydrogenase small subunit.
 
 
 
 0.863
hypA
Hydrogenase nickel incorporation protein HypA/HybF; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
   
 0.859
SHO46435.1
Hydrogenase large subunit.
 
 
 
 0.827
Your Current Organism:
Desulfopila aestuarii
NCBI taxonomy Id: 1121416
Other names: D. aestuarii DSM 18488, Desulfopila aestuarii DSM 18488
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.