SHO52877.1 protein (Desulfopila aestuarii) - STRING interaction network

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second shell of interactors

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Edges represent protein-protein associations

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

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[Homology]

Score

SHO52877.1

5-methylcytosine-specific restriction endonuclease McrA. (153 aa)

Predicted Functional Partners:

SHO52873.1

0.973

SHO52875.1

0.971

SHO52867.1

0.887

SHO52861.1

0.855

SHO53470.1

0.849

SHO52858.1

0.790

SHO52872.1

0.773

SHO52879.1

0.773

SHO52880.1

0.773

SHO47917.1

0.692

Your Current Organism:

Desulfopila aestuarii

NCBI taxonomy Id: 1121416
Other names: D. aestuarii DSM 18488, Desulfopila aestuarii DSM 18488

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SHO47917.1	SHO52877.1	SAMN02745220_02045	SAMN02745220_04814	Methanogenic corrinoid protein MtbC1.	5-methylcytosine-specific restriction endonuclease McrA.	0.692
SHO52858.1	SHO52861.1	SAMN02745220_04804	SAMN02745220_04806	Phage major capsid protein, HK97 family.	Phage portal protein, HK97 family.	0.993
SHO52858.1	SHO52867.1	SAMN02745220_04804	SAMN02745220_04809	Phage major capsid protein, HK97 family.	Phage Terminase.	0.792
SHO52858.1	SHO52873.1	SAMN02745220_04804	SAMN02745220_04812	Phage major capsid protein, HK97 family.	Phage terminase-like protein, large subunit, contains N-terminal HTH domain.	0.791
SHO52858.1	SHO52875.1	SAMN02745220_04804	SAMN02745220_04813	Phage major capsid protein, HK97 family.	Phage terminase, small subunit, putative, P27 family.	0.779
SHO52858.1	SHO52877.1	SAMN02745220_04804	SAMN02745220_04814	Phage major capsid protein, HK97 family.	5-methylcytosine-specific restriction endonuclease McrA.	0.790
SHO52861.1	SHO52858.1	SAMN02745220_04806	SAMN02745220_04804	Phage portal protein, HK97 family.	Phage major capsid protein, HK97 family.	0.993
SHO52861.1	SHO52867.1	SAMN02745220_04806	SAMN02745220_04809	Phage portal protein, HK97 family.	Phage Terminase.	0.834
SHO52861.1	SHO52873.1	SAMN02745220_04806	SAMN02745220_04812	Phage portal protein, HK97 family.	Phage terminase-like protein, large subunit, contains N-terminal HTH domain.	0.834
SHO52861.1	SHO52875.1	SAMN02745220_04806	SAMN02745220_04813	Phage portal protein, HK97 family.	Phage terminase, small subunit, putative, P27 family.	0.896
SHO52861.1	SHO52877.1	SAMN02745220_04806	SAMN02745220_04814	Phage portal protein, HK97 family.	5-methylcytosine-specific restriction endonuclease McrA.	0.855
SHO52867.1	SHO52858.1	SAMN02745220_04809	SAMN02745220_04804	Phage Terminase.	Phage major capsid protein, HK97 family.	0.792
SHO52867.1	SHO52861.1	SAMN02745220_04809	SAMN02745220_04806	Phage Terminase.	Phage portal protein, HK97 family.	0.834
SHO52867.1	SHO52875.1	SAMN02745220_04809	SAMN02745220_04813	Phage Terminase.	Phage terminase, small subunit, putative, P27 family.	0.840
SHO52867.1	SHO52877.1	SAMN02745220_04809	SAMN02745220_04814	Phage Terminase.	5-methylcytosine-specific restriction endonuclease McrA.	0.887
SHO52872.1	SHO52873.1	SAMN02745220_04811	SAMN02745220_04812	DNA binding domain-containing protein, excisionase family.	Phage terminase-like protein, large subunit, contains N-terminal HTH domain.	0.773
SHO52872.1	SHO52875.1	SAMN02745220_04811	SAMN02745220_04813	DNA binding domain-containing protein, excisionase family.	Phage terminase, small subunit, putative, P27 family.	0.773
SHO52872.1	SHO52877.1	SAMN02745220_04811	SAMN02745220_04814	DNA binding domain-containing protein, excisionase family.	5-methylcytosine-specific restriction endonuclease McrA.	0.773
SHO52872.1	SHO52879.1	SAMN02745220_04811	SAMN02745220_04815	DNA binding domain-containing protein, excisionase family.	Hypothetical protein.	0.773
SHO52872.1	SHO52880.1	SAMN02745220_04811	SAMN02745220_04816	DNA binding domain-containing protein, excisionase family.	Helix-turn-helix domain-containing protein.	0.773

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

40

average node degree:

7.27

avg. local clustering coefficient:

0.875

expected number of edges:

11

PPI enrichment p-value:

4.94e-12

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009252

Peptidoglycan biosynthetic process

8 of 38

1.96

4.42

8.65e-12

GO:0071555

Cell wall organization

4 of 26

1.83

2.07

2.98e-05

GO:0008360

Regulation of cell shape

4 of 26

1.83

2.07

2.98e-05

GO:0051301

Cell division

3 of 44

1.47

0.99

0.0063

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008955

Peptidoglycan glycosyltransferase activity

5 of 7

2.49

4.05

1.40e-08

GO:0008658

Penicillin binding

4 of 6

2.46

3.21

7.03e-07

GO:0009002

Serine-type D-Ala-D-Ala carboxypeptidase activity

3 of 5

2.42

2.34

3.71e-05

GO:0016757

Glycosyltransferase activity

6 of 61

1.63

2.33

7.03e-07

GO:0004180

Carboxypeptidase activity

4 of 19

1.96

2.32

1.32e-05

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1359

Mixed, incl. Peptidoglycan biosynthesis, and Cell division

11 of 46

2.02

6.54

2.68e-19

CL:1363

Mixed, incl. Peptidoglycan biosynthesis, and Cell division site

9 of 33

2.07

5.85

1.83e-15

CL:1416

Peptidoglycan glycosyltransferase activity, and Peptidoglycan muralytic activity

4 of 5

2.54

3.48

2.33e-07

CL:1365

Mixed, incl. Cell shape, and Cell division site

5 of 23

1.98

3.01

2.35e-07

CL:1398

Mixed, incl. Cell cycle protein, and Cell morphogenesis

2 of 5

2.24

1.07

0.0102

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00550

Peptidoglycan biosynthesis

6 of 33

1.9

3.33

1.15e-08

map01501

beta-Lactam resistance

4 of 121

1.16

0.79

0.0083

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032153

Cell division site

3 of 9

2.16

1.68

0.00059

GOCC:0005618

Cell wall

3 of 21

1.79

1.26

0.0027

GOCC:0071944

Cell periphery

7 of 713

0.63

0.39

0.0319

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0961

Cell wall biogenesis/degradation

3 of 16

1.91

1.38

0.0018

KW-0133

Cell shape

3 of 16

1.91

1.38

0.0018

KW-0997

Cell inner membrane

3 of 42

1.49

0.94

0.0087

KW-0573

Peptidoglycan synthesis

2 of 15

1.76

0.87

0.0198

KW-0328

Glycosyltransferase

2 of 22

1.6

0.73

0.0348

(more ...)

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00905

Penicillin binding protein transpeptidase domain

4 of 6

2.46

2.98

2.11e-06

PF03717

Penicillin-binding Protein dimerisation domain

2 of 2

2.64

1.11

0.0097

PF01098

Cell cycle protein

2 of 2

2.64

1.11

0.0097

PF00912

Transglycosylase

2 of 4

2.34

1.04

0.0120

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001460

Penicillin-binding protein, transpeptidase

4 of 6

2.46

2.92

2.73e-06

IPR012338

Beta-lactamase/transpeptidase-like

5 of 18

2.08

2.84

1.26e-06

IPR036138

Penicillin-binding protein, dimerisation domain superfamily

2 of 2

2.64

0.98

0.0167

IPR005311

Penicillin-binding protein, dimerisation domain

2 of 2

2.64

0.98

0.0167

IPR001182

Probable peptidoglycan glycosyltransferase FtsW/RodA

2 of 2

2.64

0.98

0.0167

(more ...)

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