STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pnpPutative polynucleotide phosphorylase/polyadenylase; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction. (764 aa)    
Predicted Functional Partners:
infB
Putative translation initiation factor IF-2; One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.
  
  
 0.984
DGI_1169
Putative DEAD/DEAH box helicase domain protein.
  
 
 0.971
nusA
Putative transcription termination factor NusA; Participates in both transcription termination and antitermination.
 
  
 0.948
DGI_2879
Putative ribonuclease, Rne/Rng family.
  
 
 0.944
rpoB
Putative DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
  
  
 0.919
rplC
Putative 50S ribosomal protein L3; One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit; Belongs to the universal ribosomal protein uL3 family.
 
  
 0.914
rplD
Putative ribosomal protein L4/L1 family protein; Forms part of the polypeptide exit tunnel.
 
    0.909
eno
Putative phosphopyruvate hydratase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
  
 
 0.897
rho
Putative transcription termination factor Rho; Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA- dependent ATPase activity, and release of the mRNA from the DNA template.
   
  
 0.896
DGI_2281
Putative polymerase family protein; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
  
 
 0.894
Your Current Organism:
Desulfovibrio gigas
NCBI taxonomy Id: 1121448
Other names: D. gigas DSM 1382 = ATCC 19364, Desulfovibrio gigas ATCC 19364, Desulfovibrio gigas DSM 1382 = ATCC 19364
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.