STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metKS-adenosylmethionine synthase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. (396 aa)    
Predicted Functional Partners:
OMW_01382
5-methyltetrahydropteroyltriglutamate- homocysteine methyltransferase.
  
 0.984
metE
5-methyltetrahydropteroyltriglutamate- homocysteine S-methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family.
  
 0.956
OMW_00133
Hypothetical protein.
  
 0.930
OMW_01376
5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
  
 
 0.839
OMW_00588
Hypothetical protein.
   
 0.835
OMW_01301
Hypothetical protein.
   
 0.835
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
 
  
 0.762
mscL
Large conductance mechanosensitive channel protein; Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.
   
    0.749
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine; In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.
 
  
 0.743
OMW_01816
Hypothetical protein.
   
 0.742
Your Current Organism:
Enterococcus columbae
NCBI taxonomy Id: 1121865
Other names: E. columbae DSM 7374 = ATCC 51263, Enterococcus columbae ATCC 51263, Enterococcus columbae ATCC 51263 = DMS 7374, Enterococcus columbae CCUG 27894, Enterococcus columbae CIP 103675, Enterococcus columbae DSM 7374, Enterococcus columbae DSM 7374 = ATCC 51263, Enterococcus columbae EnGen0384, Enterococcus columbae LMG 11740, Enterococcus columbae NBRC 100677, Enterococcus columbae NCFB 13013, Enterococcus columbae NCIMB 13013, Enterococcus columbae STR 345
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