GCA_000379765_01554 protein (Flexithrix dorotheae)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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Gene Fusion

Cooccurrence

Coexpression

Experiments

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[Homology]

Score

GCA_000379765_01554

Unannotated protein. (452 aa)

Predicted Functional Partners:

GCA_000379765_01555

0.977

GCA_000379765_00782

0.718

GCA_000379765_04972

0.631

GCA_000379765_00369

0.622

GCA_000379765_01231

0.544

GCA_000379765_04313

0.544

GCA_000379765_01870

0.514

GCA_000379765_01347

0.450

GCA_000379765_04336

0.428

GCA_000379765_03946

0.424

Your Current Organism:

Flexithrix dorotheae

NCBI taxonomy Id: 1121904
Other names: F. dorotheae DSM 6795, Flexithrix dorotheae DSM 6795

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structured XML interaction data, according to the 'PSI-MI' data standard

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Browse interactions in tabular form:

node1	node2	node1 annotation	node2 annotation	score
GCA_000379765_00369	GCA_000379765_00782	Unannotated protein.	Unannotated protein.	0.873
GCA_000379765_00369	GCA_000379765_01231	Unannotated protein.	Unannotated protein.	0.865
GCA_000379765_00369	GCA_000379765_01554	Unannotated protein.	Unannotated protein.	0.622
GCA_000379765_00369	GCA_000379765_04313	Unannotated protein.	Unannotated protein.	0.865
GCA_000379765_00369	GCA_000379765_04972	Unannotated protein.	Unannotated protein.	0.563
GCA_000379765_00782	GCA_000379765_00369	Unannotated protein.	Unannotated protein.	0.873
GCA_000379765_00782	GCA_000379765_01231	Unannotated protein.	Unannotated protein.	0.955
GCA_000379765_00782	GCA_000379765_01554	Unannotated protein.	Unannotated protein.	0.718
GCA_000379765_00782	GCA_000379765_01555	Unannotated protein.	Unannotated protein.	0.692
GCA_000379765_00782	GCA_000379765_04313	Unannotated protein.	Unannotated protein.	0.954
GCA_000379765_00782	GCA_000379765_04972	Unannotated protein.	Unannotated protein.	0.873
GCA_000379765_01231	GCA_000379765_00369	Unannotated protein.	Unannotated protein.	0.865
GCA_000379765_01231	GCA_000379765_00782	Unannotated protein.	Unannotated protein.	0.955
GCA_000379765_01231	GCA_000379765_01347	Unannotated protein.	Unannotated protein.	0.615
GCA_000379765_01231	GCA_000379765_01554	Unannotated protein.	Unannotated protein.	0.544
GCA_000379765_01231	GCA_000379765_01555	Unannotated protein.	Unannotated protein.	0.538
GCA_000379765_01231	GCA_000379765_04313	Unannotated protein.	Unannotated protein.	0.999
GCA_000379765_01231	GCA_000379765_04336	Unannotated protein.	Unannotated protein.	0.615
GCA_000379765_01231	GCA_000379765_04972	Unannotated protein.	Unannotated protein.	0.865
GCA_000379765_01347	GCA_000379765_01231	Unannotated protein.	Unannotated protein.	0.615

page 1 of 3

Network Stats

number of nodes:

11

number of edges:

38

average node degree:

6.91

avg. local clustering coefficient:

0.929

expected number of edges:

15

PPI enrichment p-value:

3.88e-07

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0033014

Tetrapyrrole biosynthetic process

11 of 21

2.07

6.86

2.33e-19

GO:0009236

Cobalamin biosynthetic process

10 of 16

2.15

6.83

7.88e-18

GO:0032259

Methylation

6 of 59

1.36

1.69

4.61e-06

GO:0006541

Glutamine metabolic process

2 of 11

1.61

0.67

0.0474

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008168

Methyltransferase activity

6 of 57

1.38

1.51

4.80e-05

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:35864536

(2022) Metagenomic insights into the microbe-mediated B and K2 vitamin biosynthesis in the gastrointestinal microbiome of ruminants.

8 of 10

2.26

6.17

1.52e-14

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:3483

Cobalamin metabolic process

10 of 10

2.35

8.09

4.45e-19

CL:3480

Tetrapyrrole biosynthetic process, and ABC transporter, permease protein, BtuC-like

11 of 31

1.9

5.72

2.08e-18

CL:3485

Tetrapyrrole methylase

5 of 5

2.35

3.97

1.14e-08

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00860

Porphyrin and chlorophyll metabolism

11 of 44

1.75

4.72

2.22e-17

map01100

Metabolic pathways

11 of 814

0.48

0.41

0.00026

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0169

Cobalamin biosynthesis

4 of 6

2.18

2.56

8.09e-06

KW-0489

Methyltransferase

5 of 48

1.37

1.4

0.00014

KW-0949

S-adenosyl-L-methionine

3 of 34

1.3

0.68

0.0290

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00590

Tetrapyrrole (Corrin/Porphyrin) Methylases

5 of 6

2.27

3.47

1.09e-07

PF07685

CobB/CobQ-like glutamine amidotransferase domain

2 of 3

2.18

0.78

0.0363

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR035996

Tetrapyrrole methylase superfamily

5 of 6

2.27

3.28

2.81e-07

IPR014777

Tetrapyrrole methylase, subdomain 1

5 of 6

2.27

3.28

2.81e-07

IPR014776

Tetrapyrrole methylase, subdomain 2

5 of 6

2.27

3.28

2.81e-07

IPR000878

Tetrapyrrole methylase

5 of 6

2.27

3.28

2.81e-07

IPR011698

CobB/CobQ-like glutamine amidotransferase

2 of 2

2.35

0.9

0.0225

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