STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ccmCHeme ABC transporter permease; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmC/CycZ/HelC family. (246 aa)    
Predicted Functional Partners:
ccmE
Hypothetical protein; Heme chaperone required for the biogenesis of c-type cytochromes. Transiently binds heme delivered by CcmC and transfers the heme to apo-cytochromes in a process facilitated by CcmF and CcmH. Belongs to the CcmE/CycJ family.
 
 
 0.999
EPC02813.1
Hypothetical protein; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmD/CycX/HelD family.
 
 
 0.999
EPC02815.1
Heme exporter protein B; Required for the export of heme to the periplasm for the biogenesis of c-type cytochromes; Belongs to the CcmB/CycW/HelB family.
 
 0.999
ccmA
Cytochrome C biogenesis protein CcmA; Part of the ABC transporter complex CcmAB involved in the biogenesis of c-type cytochromes; once thought to export heme, this seems not to be the case, but its exact role is uncertain. Responsible for energy coupling to the transport system; Belongs to the ABC transporter superfamily. CcmA exporter (TC 3.A.1.107) family.
 
 0.999
EPC02810.1
Thiol oxidoreductase DsbE; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
 
  
 0.987
EPC02809.1
Hypothetical protein; Possible subunit of a heme lyase.
 
   
 0.980
EPC02808.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
 
  
 0.969
EPC02811.1
Heme lyase subunit CcmF; Cytochrome c-type biogenesis protein; required for the transfer of heme to apocytochrome c; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
 
     0.968
smc
Hypothetical protein; Required for chromosome condensation and partitioning. Belongs to the SMC family.
       0.865
nuoC
Bifunctional NADH:ubiquinone oxidoreductase subunit C/D; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient; In the C-terminal section; belongs to the complex I 49 kDa subunit family.
   
  
 0.801
Your Current Organism:
Halomonas anticariensis
NCBI taxonomy Id: 1121939
Other names: H. anticariensis FP35 = DSM 16096, Halomonas anticariensis DSM 16096, Halomonas anticariensis DSM 16096 = FP35, Halomonas anticariensis FP35, Halomonas anticariensis FP35 = DSM 16096
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