SHJ02178.1 protein (Lutispora thermophila) - STRING interaction network

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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protein homology

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Score

SHJ02178.1

MFS-type transporter involved in bile tolerance, Atg22 family. (402 aa)

Predicted Functional Partners:

SHI75546.1

0.769

SHJ02111.1

0.738

SHJ02131.1

0.732

SHI84466.1

0.718

SHJ02160.1

0.718

SHJ02333.1

0.694

SHJ01936.1

0.611

SHJ02086.1

0.589

SHJ02067.1

0.556

SHI77014.1

0.547

Your Current Organism:

Lutispora thermophila

NCBI taxonomy Id: 1122184
Other names: Clostridium sp. EBR-02E-0046, L. thermophila DSM 19022, Lutispora thermophila DSM 19022, Lutispora thermophila EBR46

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SHI75546.1	SHI77014.1	SAMN02745176_01237	SAMN02745176_01306	Chorismate mutase.	PAS/PAC sensor hybrid histidine kinase.	0.955
SHI75546.1	SHI84466.1	SAMN02745176_01237	SAMN02745176_01548	Chorismate mutase.	5-methyltetrahydrofolate--homocysteine methyltransferase.	0.858
SHI75546.1	SHJ02086.1	SAMN02745176_01237	SAMN02745176_02139	Chorismate mutase.	Hypothetical protein.	0.497
SHI75546.1	SHJ02111.1	SAMN02745176_01237	SAMN02745176_02140	Chorismate mutase.	Hypothetical protein.	0.496
SHI75546.1	SHJ02178.1	SAMN02745176_01237	SAMN02745176_02143	Chorismate mutase.	MFS-type transporter involved in bile tolerance, Atg22 family.	0.769
SHI75546.1	SHJ02333.1	SAMN02745176_01237	SAMN02745176_02151	Chorismate mutase.	MFS transporter, DHA3 family, macrolide efflux protein.	0.769
SHI77014.1	SHI75546.1	SAMN02745176_01306	SAMN02745176_01237	PAS/PAC sensor hybrid histidine kinase.	Chorismate mutase.	0.955
SHI77014.1	SHI84466.1	SAMN02745176_01306	SAMN02745176_01548	PAS/PAC sensor hybrid histidine kinase.	5-methyltetrahydrofolate--homocysteine methyltransferase.	0.539
SHI77014.1	SHJ01936.1	SAMN02745176_01306	SAMN02745176_02132	PAS/PAC sensor hybrid histidine kinase.	Formate dehydrogenase major subunit.	0.862
SHI77014.1	SHJ02086.1	SAMN02745176_01306	SAMN02745176_02139	PAS/PAC sensor hybrid histidine kinase.	Hypothetical protein.	0.458
SHI77014.1	SHJ02131.1	SAMN02745176_01306	SAMN02745176_02141	PAS/PAC sensor hybrid histidine kinase.	Nucleoside-diphosphate-sugar epimerase.	0.405
SHI77014.1	SHJ02178.1	SAMN02745176_01306	SAMN02745176_02143	PAS/PAC sensor hybrid histidine kinase.	MFS-type transporter involved in bile tolerance, Atg22 family.	0.547
SHI77014.1	SHJ02333.1	SAMN02745176_01306	SAMN02745176_02151	PAS/PAC sensor hybrid histidine kinase.	MFS transporter, DHA3 family, macrolide efflux protein.	0.547
SHI84466.1	SHI75546.1	SAMN02745176_01548	SAMN02745176_01237	5-methyltetrahydrofolate--homocysteine methyltransferase.	Chorismate mutase.	0.858
SHI84466.1	SHI77014.1	SAMN02745176_01548	SAMN02745176_01306	5-methyltetrahydrofolate--homocysteine methyltransferase.	PAS/PAC sensor hybrid histidine kinase.	0.539
SHI84466.1	SHJ01936.1	SAMN02745176_01548	SAMN02745176_02132	5-methyltetrahydrofolate--homocysteine methyltransferase.	Formate dehydrogenase major subunit.	0.861
SHI84466.1	SHJ02178.1	SAMN02745176_01548	SAMN02745176_02143	5-methyltetrahydrofolate--homocysteine methyltransferase.	MFS-type transporter involved in bile tolerance, Atg22 family.	0.718
SHI84466.1	SHJ02333.1	SAMN02745176_01548	SAMN02745176_02151	5-methyltetrahydrofolate--homocysteine methyltransferase.	MFS transporter, DHA3 family, macrolide efflux protein.	0.708
SHJ01936.1	SHI77014.1	SAMN02745176_02132	SAMN02745176_01306	Formate dehydrogenase major subunit.	PAS/PAC sensor hybrid histidine kinase.	0.862
SHJ01936.1	SHI84466.1	SAMN02745176_02132	SAMN02745176_01548	Formate dehydrogenase major subunit.	5-methyltetrahydrofolate--homocysteine methyltransferase.	0.861

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Network Stats

number of nodes:

11

number of edges:

41

average node degree:

7.45

avg. local clustering coefficient:

0.877

expected number of edges:

21

PPI enrichment p-value:

7.17e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006633

Fatty acid biosynthetic process

7 of 19

2.08

4.33

1.57e-10

GO:2001295

malonyl-CoA biosynthetic process

2 of 5

2.12

1.02

0.0124

GO:0006814

Sodium ion transport

2 of 7

1.97

0.92

0.0180

GO:0044249

Cellular biosynthetic process

9 of 667

0.65

0.52

0.00085

GO:1901576

Organic substance biosynthetic process

9 of 706

0.62

0.49

0.0013

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004312

Fatty acid synthase activity

4 of 8

2.22

2.45

1.52e-05

GO:0016747

Acyltransferase activity, transferring groups other than amino-acyl groups

5 of 44

1.57

1.73

5.39e-05

GO:0003989

acetyl-CoA carboxylase activity

2 of 2

2.52

1.13

0.0085

GO:0004315

3-oxoacyl-[acyl-carrier-protein] synthase activity

2 of 3

2.34

1.06

0.0113

GO:0016743

Carboxyl- or carbamoyltransferase activity

2 of 5

2.12

0.91

0.0198

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009317

acetyl-CoA carboxylase complex

2 of 5

2.12

0.89

0.0219

GO:0005622

Intracellular anatomical structure

10 of 1227

0.43

0.31

0.0219

GO:0005737

Cytoplasm

9 of 1122

0.42

0.29

0.0361

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1452

malonyl-CoA metabolic process, and 3-oxoacyl-[acyl-carrier-protein] synthase activity

7 of 11

2.32

5.37

4.79e-12

CL:1448

Mixed, incl. Fatty acid biosynthetic process, and AMP-binding enzyme C-terminal domain

8 of 32

1.92

4.32

6.31e-12

CL:1454

Fatty acid metabolism, and acetyl-CoA carboxylase activity

5 of 6

2.44

4.17

6.11e-09

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00061

Fatty acid biosynthesis

6 of 15

2.12

4.13

8.47e-10

map01212

Fatty acid metabolism

6 of 21

1.97

3.71

2.29e-09

map00620

Pyruvate metabolism

5 of 70

1.37

1.5

5.01e-05

map01200

Carbon metabolism

5 of 145

1.05

0.88

0.0012

map00780

Biotin metabolism

2 of 14

1.67

0.87

0.0178

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0009317

acetyl-CoA carboxylase complex

4 of 9

2.17

2.53

8.98e-06

GOCC:0005737

Cytoplasm

10 of 855

0.59

0.48

0.00068

GOCC:0005622

Intracellular

11 of 1191

0.48

0.4

0.00068

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0444

Lipid biosynthesis

4 of 17

1.89

2.03

5.00e-05

KW-0012

Acyltransferase

3 of 17

1.76

1.37

0.0014

KW-0275

Fatty acid biosynthesis

2 of 6

2.04

1.08

0.0087

KW-0808

Transferase

6 of 311

0.8

0.57

0.0063

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