STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SHJ12305.1RNA polymerase, sigma subunit, RpoX/SigF; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. (245 aa)    
Predicted Functional Partners:
spoIIAB
Stage II sporulation protein AB (anti-sigma F factor); Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
 
 
 0.995
SHJ12271.1
Anti-anti-sigma regulatory factor, SpoIIAA; Belongs to the anti-sigma-factor antagonist family.
 
  
 0.967
SHJ00208.1
Anti-sigma regulatory factor (Ser/Thr protein kinase).
  
 
 0.890
SHI93173.1
Two-component system, response regulator, stage 0 sporulation protein A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
  
   
 0.816
SHI73557.1
Stage V sporulation protein AE.
 
     0.789
SHI73583.1
Stage V sporulation protein AD.
 
     0.768
SHI73600.1
Stage V sporulation protein AC.
 
     0.751
SHI63001.1
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
     0.744
SHI92121.1
RNA polymerase sporulation-specific sigma factor.
  
   
 0.736
SHI38023.1
Putative DeoR family transcriptional regulator, stage III sporulation protein D.
  
   
 0.725
Your Current Organism:
Lutispora thermophila
NCBI taxonomy Id: 1122184
Other names: Clostridium sp. EBR-02E-0046, L. thermophila DSM 19022, Lutispora thermophila DSM 19022, Lutispora thermophila EBR46
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.