hslV protein (Maritalea myrionectae) - STRING interaction network

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Score

hslV

Unannotated protein; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. (187 aa)

Predicted Functional Partners:

hslU

0.999

grpE

0.894

dnaJ

0.878

MXMO3_00317

0.836

groL

0.815

groS

0.808

lon

0.791

MXMO3_00277

0.780

MXMO3_00275

0.773

dnaK

0.749

Your Current Organism:

Maritalea myrionectae

NCBI taxonomy Id: 1122213
Other names: M. myrionectae DSM 19524, Maritalea myrionectae DSM 19524

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MXMO3_00275	MXMO3_00277	GCA_000423365_02988	GCA_000423365_02990	Unannotated protein.	Unannotated protein.	0.773
MXMO3_00275	hslU	GCA_000423365_02988	GCA_000423365_02991	Unannotated protein.	Unannotated protein; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.	0.714
MXMO3_00275	hslV	GCA_000423365_02988	GCA_000423365_02989	Unannotated protein.	Unannotated protein; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.	0.773
MXMO3_00277	MXMO3_00275	GCA_000423365_02990	GCA_000423365_02988	Unannotated protein.	Unannotated protein.	0.773
MXMO3_00277	hslU	GCA_000423365_02990	GCA_000423365_02991	Unannotated protein.	Unannotated protein; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.	0.724
MXMO3_00277	hslV	GCA_000423365_02990	GCA_000423365_02989	Unannotated protein.	Unannotated protein; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.	0.780
MXMO3_00317	dnaJ	GCA_000423365_03029	GCA_000423365_02971	Unannotated protein.	Unannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...]	0.742
MXMO3_00317	dnaK	GCA_000423365_03029	GCA_000423365_02970	Unannotated protein.	Unannotated protein; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.559
MXMO3_00317	groL	GCA_000423365_03029	GCA_000423365_00446	Unannotated protein.	Unannotated protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.702
MXMO3_00317	groS	GCA_000423365_03029	GCA_000423365_00445	Unannotated protein.	Unannotated protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.623
MXMO3_00317	grpE	GCA_000423365_03029	GCA_000423365_02966	Unannotated protein.	Unannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...]	0.844
MXMO3_00317	hslU	GCA_000423365_03029	GCA_000423365_02991	Unannotated protein.	Unannotated protein; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.	0.850
MXMO3_00317	hslV	GCA_000423365_03029	GCA_000423365_02989	Unannotated protein.	Unannotated protein; Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery.	0.836
MXMO3_00317	lon	GCA_000423365_03029	GCA_000423365_02327	Unannotated protein.	Unannotated protein; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.	0.558
dnaJ	MXMO3_00317	GCA_000423365_02971	GCA_000423365_03029	Unannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...]	Unannotated protein.	0.742
dnaJ	dnaK	GCA_000423365_02971	GCA_000423365_02970	Unannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...]	Unannotated protein; Acts as a chaperone; Belongs to the heat shock protein 70 family.	0.998
dnaJ	groL	GCA_000423365_02971	GCA_000423365_00446	Unannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...]	Unannotated protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions.	0.923
dnaJ	groS	GCA_000423365_02971	GCA_000423365_00445	Unannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...]	Unannotated protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter.	0.835
dnaJ	grpE	GCA_000423365_02971	GCA_000423365_02966	Unannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...]	Unannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depe [...]	0.969
dnaJ	hslU	GCA_000423365_02971	GCA_000423365_02991	Unannotated protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK [...]	Unannotated protein; ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.	0.907