node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SIS29463.1 | SIS29566.1 | SAMN05421768_101622 | SAMN05421768_101681 | Cystathionine beta-synthase. | Serine O-acetyltransferase. | 0.967 |
SIS29463.1 | SIS31488.1 | SAMN05421768_101622 | SAMN05421768_102397 | Cystathionine beta-synthase. | Cystathionine gamma-lyase. | 0.978 |
SIS29463.1 | SIS33776.1 | SAMN05421768_101622 | SAMN05421768_103427 | Cystathionine beta-synthase. | Serine O-acetyltransferase. | 0.964 |
SIS29463.1 | SIS34192.1 | SAMN05421768_101622 | SAMN05421768_103639 | Cystathionine beta-synthase. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.916 |
SIS29463.1 | ahcY | SAMN05421768_101622 | SAMN05421768_102251 | Cystathionine beta-synthase. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.923 |
SIS29463.1 | glyA | SAMN05421768_101622 | SAMN05421768_102549 | Cystathionine beta-synthase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.922 |
SIS29463.1 | ilvA | SAMN05421768_101622 | SAMN05421768_104179 | Cystathionine beta-synthase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.916 |
SIS29463.1 | metE | SAMN05421768_101622 | SAMN05421768_101662 | Cystathionine beta-synthase. | Methionine synthase (B12-independent); Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.913 |
SIS29463.1 | metZ | SAMN05421768_101622 | SAMN05421768_103637 | Cystathionine beta-synthase. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.971 |
SIS29463.1 | trpA | SAMN05421768_101622 | SAMN05421768_104325 | Cystathionine beta-synthase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.913 |
SIS29566.1 | SIS29463.1 | SAMN05421768_101681 | SAMN05421768_101622 | Serine O-acetyltransferase. | Cystathionine beta-synthase. | 0.967 |
SIS29566.1 | SIS31488.1 | SAMN05421768_101681 | SAMN05421768_102397 | Serine O-acetyltransferase. | Cystathionine gamma-lyase. | 0.851 |
SIS29566.1 | SIS33776.1 | SAMN05421768_101681 | SAMN05421768_103427 | Serine O-acetyltransferase. | Serine O-acetyltransferase. | 0.926 |
SIS29566.1 | glyA | SAMN05421768_101681 | SAMN05421768_102549 | Serine O-acetyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.823 |
SIS29566.1 | ilvA | SAMN05421768_101681 | SAMN05421768_104179 | Serine O-acetyltransferase. | L-threonine ammonia-lyase; Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.811 |
SIS29566.1 | trpA | SAMN05421768_101681 | SAMN05421768_104325 | Serine O-acetyltransferase. | Tryptophan synthase, alpha chain; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.810 |
SIS31488.1 | SIS29463.1 | SAMN05421768_102397 | SAMN05421768_101622 | Cystathionine gamma-lyase. | Cystathionine beta-synthase. | 0.978 |
SIS31488.1 | SIS29566.1 | SAMN05421768_102397 | SAMN05421768_101681 | Cystathionine gamma-lyase. | Serine O-acetyltransferase. | 0.851 |
SIS31488.1 | SIS33776.1 | SAMN05421768_102397 | SAMN05421768_103427 | Cystathionine gamma-lyase. | Serine O-acetyltransferase. | 0.851 |
SIS31488.1 | SIS34192.1 | SAMN05421768_102397 | SAMN05421768_103639 | Cystathionine gamma-lyase. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.948 |