node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SMC37174.1 | SMC87653.1 | SAMN02745168_0521 | SAMN02745168_0185 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Phosphoribosylformylglycinamidine synthase. | 0.674 |
SMC37174.1 | hisA | SAMN02745168_0521 | SAMN02745168_0519 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.999 |
SMC37174.1 | hisB | SAMN02745168_0521 | SAMN02745168_0517 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Imidazoleglycerol-phosphate dehydratase. | 0.999 |
SMC37174.1 | hisC | SAMN02745168_0521 | SAMN02745168_0495 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.950 |
SMC37174.1 | hisD | SAMN02745168_0521 | SAMN02745168_0516 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
SMC37174.1 | hisE | SAMN02745168_0521 | SAMN02745168_0522 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | phosphoribosyl-ATP pyrophosphatase. | 0.999 |
SMC37174.1 | hisF | SAMN02745168_0521 | SAMN02745168_0520 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.999 |
SMC37174.1 | hisG | SAMN02745168_0521 | SAMN02745168_0515 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.998 |
SMC37174.1 | hisH | SAMN02745168_0521 | SAMN02745168_0518 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.998 |
SMC37174.1 | hisZ | SAMN02745168_0521 | SAMN02745168_0514 | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | ATP phosphoribosyltransferase regulatory subunit; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.984 |
SMC87653.1 | SMC37174.1 | SAMN02745168_0185 | SAMN02745168_0521 | Phosphoribosylformylglycinamidine synthase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | 0.674 |
SMC87653.1 | hisA | SAMN02745168_0185 | SAMN02745168_0519 | Phosphoribosylformylglycinamidine synthase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.568 |
SMC87653.1 | hisB | SAMN02745168_0185 | SAMN02745168_0517 | Phosphoribosylformylglycinamidine synthase. | Imidazoleglycerol-phosphate dehydratase. | 0.615 |
SMC87653.1 | hisD | SAMN02745168_0185 | SAMN02745168_0516 | Phosphoribosylformylglycinamidine synthase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.770 |
SMC87653.1 | hisF | SAMN02745168_0185 | SAMN02745168_0520 | Phosphoribosylformylglycinamidine synthase. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.640 |
hisA | SMC37174.1 | SAMN02745168_0519 | SAMN02745168_0521 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP; Belongs to the PRA-CH family. | 0.999 |
hisA | SMC87653.1 | SAMN02745168_0519 | SAMN02745168_0185 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Phosphoribosylformylglycinamidine synthase. | 0.568 |
hisA | hisB | SAMN02745168_0519 | SAMN02745168_0517 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Imidazoleglycerol-phosphate dehydratase. | 0.998 |
hisA | hisC | SAMN02745168_0519 | SAMN02745168_0495 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Histidinol-phosphate aminotransferase; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.959 |
hisA | hisD | SAMN02745168_0519 | SAMN02745168_0516 | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.999 |