node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SMC40199.1 | SMC53707.1 | SAMN02745168_0703 | SAMN02745168_1343 | Tetratricopeptide repeat-containing protein. | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | 0.890 |
SMC40199.1 | SMC68784.1 | SAMN02745168_0703 | SAMN02745168_2061 | Tetratricopeptide repeat-containing protein. | ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | 0.890 |
SMC40199.1 | SMC72775.1 | SAMN02745168_0703 | SAMN02745168_2231 | Tetratricopeptide repeat-containing protein. | Hsp70 protein. | 0.995 |
SMC40199.1 | SMC72792.1 | SAMN02745168_0703 | SAMN02745168_2232 | Tetratricopeptide repeat-containing protein. | Hsp70 protein. | 0.994 |
SMC40199.1 | clpB | SAMN02745168_0703 | SAMN02745168_0793 | Tetratricopeptide repeat-containing protein. | ATP-dependent Clp protease ATP-binding subunit ClpB; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE; Belongs to the ClpA/ClpB family. | 0.890 |
SMC40199.1 | groL | SAMN02745168_0703 | SAMN02745168_1546 | Tetratricopeptide repeat-containing protein. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.967 |
SMC40199.1 | groS | SAMN02745168_0703 | SAMN02745168_1545 | Tetratricopeptide repeat-containing protein. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.897 |
SMC40199.1 | grpE | SAMN02745168_0703 | SAMN02745168_2230 | Tetratricopeptide repeat-containing protein. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.994 |
SMC40199.1 | hrcA | SAMN02745168_0703 | SAMN02745168_2228 | Tetratricopeptide repeat-containing protein. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.939 |
SMC40199.1 | htpG | SAMN02745168_0703 | SAMN02745168_1358 | Tetratricopeptide repeat-containing protein. | Molecular chaperone HtpG; Molecular chaperone. Has ATPase activity. | 0.994 |
SMC53707.1 | SMC40199.1 | SAMN02745168_1343 | SAMN02745168_0703 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Tetratricopeptide repeat-containing protein. | 0.890 |
SMC53707.1 | SMC72775.1 | SAMN02745168_1343 | SAMN02745168_2231 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Hsp70 protein. | 0.919 |
SMC53707.1 | SMC72792.1 | SAMN02745168_1343 | SAMN02745168_2232 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Hsp70 protein. | 0.919 |
SMC53707.1 | groL | SAMN02745168_1343 | SAMN02745168_1546 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Chaperonin GroEL; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.716 |
SMC53707.1 | groS | SAMN02745168_1343 | SAMN02745168_1545 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Chaperonin GroES; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.704 |
SMC53707.1 | grpE | SAMN02745168_1343 | SAMN02745168_2230 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...] | 0.850 |
SMC53707.1 | hrcA | SAMN02745168_1343 | SAMN02745168_2228 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Heat-inducible transcription repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.700 |
SMC53707.1 | htpG | SAMN02745168_1343 | SAMN02745168_1358 | ATP-dependent Clp protease ATP-binding subunit ClpC; Belongs to the ClpA/ClpB family. | Molecular chaperone HtpG; Molecular chaperone. Has ATPase activity. | 0.751 |
SMC68784.1 | SMC40199.1 | SAMN02745168_2061 | SAMN02745168_0703 | ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | Tetratricopeptide repeat-containing protein. | 0.890 |
SMC68784.1 | SMC72775.1 | SAMN02745168_2061 | SAMN02745168_2231 | ATP-dependent Clp protease ATP-binding subunit ClpA; Belongs to the ClpA/ClpB family. | Hsp70 protein. | 0.919 |